CAJ | 학술논문

目的：探讨奥氮平和帕利哌酮对首发精神分裂症患者糖代谢的影响。方法：76例首发精神分裂症患者随机分为两组，分别给予奥氮平治疗（38例，奥氮平组）和帕利哌酮治疗（38例，帕利哌酮组）。两组患者治疗前和治疗后第4周末做糖耐量试验，测定空腹胰岛素、C肽、甘油三酯、胆固醇、瘦素，并测量身高、体重，计算体重指数[BMI，体重（kg）／身高（m2）]。共观察4周。结果：治疗第4周末，奥氮平组餐后1h、2h的血糖值比治疗前明显升高（t＝2．47，4．75；P＜0．05），而帕利哌酮无明显变化。治疗后奥氮平组（23．5％，8例）患者糖耐量减低的发生率高于帕利哌酮组（2．7％，1例），差异有显著性（χ2＝4．542，P＜0．05）。结论：奥氮平对首发精神分裂症患者餐后血糖值的影响大于帕利哌酮。
목적：탐토오담평화파리고동대수발정신분렬증환자당대사적영향。방법：76례수발정신분렬증환자수궤분위량조，분별급여오담평치료（38례，오담평조）화파리고동치료（38례，파리고동조）。량조환자치료전화치료후제4주말주당내량시험，측정공복이도소、C태、감유삼지、담고순、수소，병측량신고、체중，계산체중지수[BMI，체중（kg）／신고（m2）]。공관찰4주。결과：치료제4주말，오담평조찬후1h、2h적혈당치비치료전명현승고（t＝2．47，4．75；P＜0．05），이파리고동무명현변화。치료후오담평조（23．5％，8례）환자당내량감저적발생솔고우파리고동조（2．7％，1례），차이유현저성（χ2＝4．542，P＜0．05）。결론：오담평대수발정신분렬증환자찬후혈당치적영향대우파리고동。
Objective:To investigate the effects of olanzapine and paliperidone on the glucose metabo-lism in schizophrenic patients.Methods:Seventy-six first-episode schizophrenic were randomly divid-ed into two groups,which treated with olanzapine and paliperidone respectively.Before and after 4-week treatment,all the patients were given oral glucose tolerance test(OGTT),and the blood glucose values were measured.The fasting serum insulin,C-peptide,cholesterol,triglyceride,and leptin concentration were also measured.The Body Mass Index( BMI) was calculated for each patient.Results:In the OGTT, after 4-week treatment,the blood glucose at the time-points of 1 and 2 hour were higher than the base-line in olanzapine group(t=2.47,4.75;P<0.05),but unchanged in paliperidone group.The rate of im-paired glucose tolerance ( IGT ) was higher in olanzapine group than that in paliperidone group (χ2 =4.542,P<0.05).Conclusion:Olanzapine has stronger effect than paliperidone on the glucose metabo-lism.