CAJ | 학술논문

目的：比较喹硫平与利培酮治疗老年精神分裂症的临床效果。方法：回顾性分析170例老年精神分裂症患者的临床资料，根据治疗方法不同将其分为喹硫平组与利培酮组，其中喹硫平组74人，利培酮组96人，比较两组治疗前后的PANSS评分及不良反应情况。结果：喹硫平组与利培酮组治疗后2周、4周、6周、8周其各项指标较治疗前均有显著改善，差异具统计学意义(P<0.05)；而喹硫平组与利培酮组各个阶段各个指标评分差异不具统计学意义(P>0.05)；喹硫平组锥体外系反应、恶主呕吐、停经泌乳等不良反应发生率显著低于利培酮组，而嗜睡发生率显著高于利培酮组，差异具统计学意义(P<0.05)；两组患者的其它不良反应发生率及总不良反应发生率差异不具显著性(P>0.05)。结论：喹硫平与利培酮对老年精神分裂症均有确切疗效，且安全性较高；喹硫平对症状的改善相对更好。
목적：비교규류평여리배동치료노년정신분렬증적림상효과。방법：회고성분석170례노년정신분렬증환자적림상자료，근거치료방법불동장기분위규류평조여리배동조，기중규류평조74인，리배동조96인，비교량조치료전후적PANSS평분급불량반응정황。결과：규류평조여리배동조치료후2주、4주、6주、8주기각항지표교치료전균유현저개선，차이구통계학의의(P<0.05)；이규류평조여리배동조각개계단각개지표평분차이불구통계학의의(P>0.05)；규류평조추체외계반응、악주구토、정경비유등불량반응발생솔현저저우리배동조，이기수발생솔현저고우리배동조，차이구통계학의의(P<0.05)；량조환자적기타불량반응발생솔급총불량반응발생솔차이불구현저성(P>0.05)。결론：규류평여리배동대노년정신분렬증균유학절료효，차안전성교고；규류평대증상적개선상대경호。
Objective: To compare the clinical effects of quetiapine and risperidone in the treatment of senile schizophrenia. Methods:retrospective analysis of the clinical data of 170 cases of elderly patients with schizophrenia, according to the different treatment methods were divided into quetiapine group and risperidone group, wherein the quetiapine group of 74 people, 96 people of risperidone group, PANSS scores and adverse reactions were compared between two groups before and after treatment. Results:the quetiapine group and risperidone group after treatment for 2 weeks, 4 weeks, 6 weeks, 8 weeks, the indicators were significantly improved than before treatment, the difference was statistically significant ( P<0.05) ; and the difference in the score of quetiapine group and risperidone group in each stage of the index was not statistically significant (P>0.05) ;quetiapine flat group extrapyramidal adverse reactions, the evil Lord vomiting, stopping lactation was significantly lower than the risperidone group, and the incidence of somnolence was significantly higher than the risperidone group, the difference was statistically signif-icant (P<0.05) ; the other two groups of patients with adverse reaction incidence rate and the total incidence of adverse reac-tions was no significant difference (P>0.05) . Conclusion: quetiapine and risperidone in schizophrenia have exact curative ef-fect on senile spirit, and high safety;the improvement of symptom of quetiapine is relatively better.