中华实验眼科杂志
中華實驗眼科雜誌
중화실험안과잡지
CHINESE JOURNAL OF EXPERIMENTAL OPHTHALMOLOGY
2015年
6期
525-530
,共6页
生物测量%近视%超声生物显微镜%眼轴%前房/超声检查%睫状体/超声检查%前房角/超声检查
生物測量%近視%超聲生物顯微鏡%眼軸%前房/超聲檢查%睫狀體/超聲檢查%前房角/超聲檢查
생물측량%근시%초성생물현미경%안축%전방/초성검사%첩상체/초성검사%전방각/초성검사
Biometry%Myopia%Microscopy,acoustic%Axial length%Anterior chamber/ultrasonography%Ciliary body/ultrasonography%Anterior chamber angle/ultrasonography
背景 近视是全球范围内主要的致盲疾病之一,目前对近视眼结构的研究多集中于角膜曲率(CC)、中央角膜厚度(CCT)、前房深度(ACD)、眼轴长度(AL)、视网膜及脉络膜改变等方面,而对于近视眼眼前节结构,如前房角形态、睫状体形态等改变的研究少见报道. 目的 测量并分析近视眼房角及相关结构形态的改变.方法 纳入2008年5月至2010年5月在青岛市第八人民医院确诊为正视或近视者149人,年龄18 ～40岁.受检者根据屈光度的不同分为正视组30人30眼、低度近视组46例46眼、中度近视组35例35眼和高度近视组38例38眼,平均屈光度分别为(0.02±0.18)、(-1.64±0.69)、(-4.56±0.66)和(-7.04±1.02)D;受检眼分别接受眼压、CC、AL测量及超声生物显微镜(UBM)和扩瞳验光等检查,观察各组间传统测量项目,如眼压、CCT、CC、AL、ACD及UBM测量指标,如房角开放距离(AOD)、虹膜厚度(IT1、IT2、IT3)、睫状体位置[A角、B角、小梁-睫状突距离(TCPD)、虹膜-睫状体距离(ICPD)]、睫状体厚度(CBT1、CBT2、CBT3)的差异.结果 正视组、低度近视组、中度近视组和高度近视组间眼压、CC、CCT值出现轻微变化,但组间差异均无统计学意义(均P＞0.05).AL随着近视程度的加深而伸长,ACD随着近视程度的增加而加深,差异均有统计学意义(均P＜0.05).各组间虹膜厚度(IT1、IT2、IT3)的差异均无统计学意义(均P＞0.05),而房角开放程度指标(TIA与AOD500)、睫状体位置(A角、B角、TCPD、ICPD)、CBT(CBT1、CBT2、CBT3)测量值均随着近视程度的增加而升高,各组间总体比较差异均有统计学意义(均P＜0.05).AOD500与ACD、睫状体位置(A角)、CBT(CBT1、CBT2)、AL均呈正相关,与屈光度呈负相关,差异均有统计学意义(r=0.573、0.513、0.325、0.398、0.542、-0.435,均P＜0.01);TIA与ACD、睫状体位置(A角)、CBT(CBT1、CBT2)、AL均呈正相关,与屈光度呈负相关,差异均有统计学意义(r=0.573、0.464、0.276、0.410、0.539、-0.435,均P＜0.01.结论 在一定程度上,随着近视屈光度的增加,近视眼ACD加深,房角开放程度增宽,CBT增加,睫状体位置后移.
揹景 近視是全毬範圍內主要的緻盲疾病之一,目前對近視眼結構的研究多集中于角膜麯率(CC)、中央角膜厚度(CCT)、前房深度(ACD)、眼軸長度(AL)、視網膜及脈絡膜改變等方麵,而對于近視眼眼前節結構,如前房角形態、睫狀體形態等改變的研究少見報道. 目的 測量併分析近視眼房角及相關結構形態的改變.方法 納入2008年5月至2010年5月在青島市第八人民醫院確診為正視或近視者149人,年齡18 ～40歲.受檢者根據屈光度的不同分為正視組30人30眼、低度近視組46例46眼、中度近視組35例35眼和高度近視組38例38眼,平均屈光度分彆為(0.02±0.18)、(-1.64±0.69)、(-4.56±0.66)和(-7.04±1.02)D;受檢眼分彆接受眼壓、CC、AL測量及超聲生物顯微鏡(UBM)和擴瞳驗光等檢查,觀察各組間傳統測量項目,如眼壓、CCT、CC、AL、ACD及UBM測量指標,如房角開放距離(AOD)、虹膜厚度(IT1、IT2、IT3)、睫狀體位置[A角、B角、小樑-睫狀突距離(TCPD)、虹膜-睫狀體距離(ICPD)]、睫狀體厚度(CBT1、CBT2、CBT3)的差異.結果 正視組、低度近視組、中度近視組和高度近視組間眼壓、CC、CCT值齣現輕微變化,但組間差異均無統計學意義(均P＞0.05).AL隨著近視程度的加深而伸長,ACD隨著近視程度的增加而加深,差異均有統計學意義(均P＜0.05).各組間虹膜厚度(IT1、IT2、IT3)的差異均無統計學意義(均P＞0.05),而房角開放程度指標(TIA與AOD500)、睫狀體位置(A角、B角、TCPD、ICPD)、CBT(CBT1、CBT2、CBT3)測量值均隨著近視程度的增加而升高,各組間總體比較差異均有統計學意義(均P＜0.05).AOD500與ACD、睫狀體位置(A角)、CBT(CBT1、CBT2)、AL均呈正相關,與屈光度呈負相關,差異均有統計學意義(r=0.573、0.513、0.325、0.398、0.542、-0.435,均P＜0.01);TIA與ACD、睫狀體位置(A角)、CBT(CBT1、CBT2)、AL均呈正相關,與屈光度呈負相關,差異均有統計學意義(r=0.573、0.464、0.276、0.410、0.539、-0.435,均P＜0.01.結論 在一定程度上,隨著近視屈光度的增加,近視眼ACD加深,房角開放程度增寬,CBT增加,睫狀體位置後移.
배경 근시시전구범위내주요적치맹질병지일,목전대근시안결구적연구다집중우각막곡솔(CC)、중앙각막후도(CCT)、전방심도(ACD)、안축장도(AL)、시망막급맥락막개변등방면,이대우근시안안전절결구,여전방각형태、첩상체형태등개변적연구소견보도. 목적 측량병분석근시안방각급상관결구형태적개변.방법 납입2008년5월지2010년5월재청도시제팔인민의원학진위정시혹근시자149인,년령18 ～40세.수검자근거굴광도적불동분위정시조30인30안、저도근시조46례46안、중도근시조35례35안화고도근시조38례38안,평균굴광도분별위(0.02±0.18)、(-1.64±0.69)、(-4.56±0.66)화(-7.04±1.02)D;수검안분별접수안압、CC、AL측량급초성생물현미경(UBM)화확동험광등검사,관찰각조간전통측량항목,여안압、CCT、CC、AL、ACD급UBM측량지표,여방각개방거리(AOD)、홍막후도(IT1、IT2、IT3)、첩상체위치[A각、B각、소량-첩상돌거리(TCPD)、홍막-첩상체거리(ICPD)]、첩상체후도(CBT1、CBT2、CBT3)적차이.결과 정시조、저도근시조、중도근시조화고도근시조간안압、CC、CCT치출현경미변화,단조간차이균무통계학의의(균P＞0.05).AL수착근시정도적가심이신장,ACD수착근시정도적증가이가심,차이균유통계학의의(균P＜0.05).각조간홍막후도(IT1、IT2、IT3)적차이균무통계학의의(균P＞0.05),이방각개방정도지표(TIA여AOD500)、첩상체위치(A각、B각、TCPD、ICPD)、CBT(CBT1、CBT2、CBT3)측량치균수착근시정도적증가이승고,각조간총체비교차이균유통계학의의(균P＜0.05).AOD500여ACD、첩상체위치(A각)、CBT(CBT1、CBT2)、AL균정정상관,여굴광도정부상관,차이균유통계학의의(r=0.573、0.513、0.325、0.398、0.542、-0.435,균P＜0.01);TIA여ACD、첩상체위치(A각)、CBT(CBT1、CBT2)、AL균정정상관,여굴광도정부상관,차이균유통계학의의(r=0.573、0.464、0.276、0.410、0.539、-0.435,균P＜0.01.결론 재일정정도상,수착근시굴광도적증가,근시안ACD가심,방각개방정도증관,CBT증가,첩상체위치후이.
Background Myopia is one of the main blinding diseases worldwide.At present,a lot of studies on ocular structure focus on the changes of corneal curvature(CC),central corneal thickness (CCT),anterior chamber depth (ACD),ocular axial length (AL) and choroid and retina,but the research of anterior chamber angle section structure form and ciliary body shape is lack.Objective This study was to measure and analyze the changes of the anterior chamber angle and related tissue structure in myopic eyes.Methods One hundred and forty-nine eyes of 149 subjects were included from May 2008 to May 2010 in Eighth Hospital of Qingdao City with the ages of 18-40years old under the informed consent.The subjects were assigned to the emmetropia group (30 eyes) ([0.02±0.18] D),low myopia group(46 eyes) ([-1.64±0.69] D),moderate myopia group (35 eyes) ([-4.56±0.66] D) and high myopia group (38 eyes) ([-7.04 ± 1.02] D).Conventional indexes including intraocular pressure (IOP),CCT,CC,AL and ACD were measured,and the indexes including chamber angel open distance (AOD),iris thickness (IT1,IT2,IT3),the position of ciliary body such as A-angel,B-angel,trabecular ciliary process distance (TCPD),irisciliary process distance (ICPD) and ciliary body thickness (CBT1,CBT2,CBT3) were measured by ultrasound biomicroscope(UBM).Results The IOP,CC and CCT values showed slight change in different groups without remarkable difference among them (all at P＞0.05).As the increase of myopic degree,AL was extended and ACD was deepened,showing significant differences among the groups (both at P＜0.05).There were no significant differences in IT1,IT2 and IT3 among the four groups (all at P＞0.05).However,the measuring values of angle opening degree (TIA and AOD500),ciliary position (A-angle,B-angle,TCPD,ICPD) and CBT (CBT1,CBT2,CBT3) elevated with the increase of myopic degree (all at P＜0.05).Positive correlations were found between AOD500 and ACD,A-angle,CBT1,CBT2,AL,negative correlations was found between AOD500 and myopic degree (r =0.573,0.513,0.325,0.398,0.542,-0.435,all at P＜0.01);Positive correlations were found between TIA and ACD,A-angle,CBT1,CBT2,AL,negative correlations was found between AOD500 and myopic degree (r =0.573,0.464,0.276,0.410,0.539,-0.435,all at P ＜ 0.01).Conclusions Within certain limits,as the increase of myopic degree,ACD deepens,the anterior chamber angle widens,ciliary process thickens and ciliary body backward shifts.
