CAJ | 학술논문

目的：通过对聚明胶肽注射液致不良反应文献的病例进行分析，探讨其引起不良反应的规律和原因，为临床合理用药提供参考。方法检索中国期刊全文数据库和万方数据库所载的聚明胶肽不良反应文献，对26篇目标文献所报道的44例病例报告进行统计分析。结果聚明胶肽注射液所致不良反应多数为速发型，91%的个案发生在30 min内；聚明胶肽致不良反应累及多个系统-器官，其中以全身性损害（62.50%）和心血管系统损害（10.94%）为主，过敏性休克和严重过敏样反应突出，同时也有新的不良反应出现。结论临床应重视聚明胶肽注射液的不良反应，加强用药监测，确保用药安全。
목적：통과대취명효태주사액치불량반응문헌적병례진행분석，탐토기인기불량반응적규률화원인，위림상합리용약제공삼고。방법검색중국기간전문수거고화만방수거고소재적취명효태불량반응문헌，대26편목표문헌소보도적44례병례보고진행통계분석。결과취명효태주사액소치불량반응다수위속발형，91%적개안발생재30 min내；취명효태치불량반응루급다개계통-기관，기중이전신성손해（62.50%）화심혈관계통손해（10.94%）위주，과민성휴극화엄중과민양반응돌출，동시야유신적불량반응출현。결론림상응중시취명효태주사액적불량반응，가강용약감측，학보용약안전。
Objective Through analyzing adverse drug reaction cases of polygeline injection to explore the regularity and cause of adverse drug reactions, provide reference for clinical rational drug use. Methods By retrieving CNKI database and Wanfang database, 44 cases of polygeline injection ADRs reported from 26 literatures were analyzed. Results Most of the ADRs are immediate response type, 91% cases happened within 30 mins, which involv multiple systems and organs including systemic lesions(62.50%) and cardiovascular lesions(10.94%). Allergic shock and severe anaphylactoid reactions are more obvious. At the same time, new ADRs are found in 44 cases. Conclusion More at tention should be paid to the ADRs of polygeline injection and the monitoring of medication should also be strengthened to ensure the safe medication.