CAJ | 학술논문

目的：探索自制治敏隔离膏联合孟鲁司特钠治疗过敏性鼻炎的安全性、有效性，旨在寻找有效的治疗过敏性鼻炎的新途径。方法：择符合标准的小儿过敏性鼻炎患儿122例，随机分为两组，治疗组62例，采用自制治敏隔离膏每日涂鼻腔1～3次，每晚口服孟鲁司特钠4～5m g一次。对照组60例，丙酸氟替卡松鼻喷雾剂每天早、晚各1次，每晚口服酮替芬0.5～1m g。两组均以1月为一个疗程。观察两组用药期间症状的变化、每日鼻炎症状评分、用药积分、复发率及不良反应等指标。结果：治疗1月，两组疗效差异不显著（P＞0.05），对照组症状好转时间短于治疗组（P＜0.01）；但6个月、12个月后治疗组复发率低（P＜0.01），远期疗效优于对照组；治疗组无不良反应发生而对照组不良反应发生率51.7%。结论：自制治敏隔离膏联合孟鲁司特钠治疗婴幼儿过敏性鼻炎疗效显著，安全性好，且少复发，开辟了治疗过敏性鼻炎的新途径，值得临床推广。
목적：탐색자제치민격리고연합맹로사특납치료과민성비염적안전성、유효성，지재심조유효적치료과민성비염적신도경。방법：택부합표준적소인과민성비염환인122례，수궤분위량조，치료조62례，채용자제치민격리고매일도비강1～3차，매만구복맹로사특납4～5m g일차。대조조60례，병산불체잡송비분무제매천조、만각1차，매만구복동체분0.5～1m g。량조균이1월위일개료정。관찰량조용약기간증상적변화、매일비염증상평분、용약적분、복발솔급불량반응등지표。결과：치료1월，량조료효차이불현저（P＞0.05），대조조증상호전시간단우치료조（P＜0.01）；단6개월、12개월후치료조복발솔저（P＜0.01），원기료효우우대조조；치료조무불량반응발생이대조조불량반응발생솔51.7%。결론：자제치민격리고연합맹로사특납치료영유인과민성비염료효현저，안전성호，차소복발，개벽료치료과민성비염적신도경，치득림상추엄。
Objective To explore the safety and effectiveness of treatment of sensitive self isolation agent combined with montelukast sodium in prevention and treatment of allergic rhinitis, a new way to search for the effective prevention and treatment of allergic rhinitis. Method 122 cases of children with allergic rhinitis in children methods selection standard, were randomly divided into two groups, treatment group 62 cases, using the self-made isolation agent applied daily to treat allergic nasal 1~3 times per night, oral montelukast sodium 4~5mg a. The control group of 60 cases, Fluticasone Propionate Nasal Spray every morning and evening of 1, per oral ketotifen 0.5~1mg. Two groups all take 1 months for a course of treatment. The changes were observed in the two groups during the treatment, the symptoms of rhinitis symptoms score, drug daily integral, recurrence rate and adverse reaction of index.Results In 1 months of treatment, the efficacy of the two groups were not significant (P > 0.05), the control group symptoms improved time was shorter in the treatment group (P < 0.01); but the 6 and 12 months after the treatment group the recurrence rate is low (P < 0.01), the long-term curative effect is better than that of the control group; the treatment group no adverse reaction while in the control group the incidence of adverse reactions was 51.7%.Conclusions Treatment of allergic isolation agent in combination with montelukast treatment of children allergic rhinitis curative effect, good safety, and less recurrence, opened up a new way of prevention and treatment of allergic rhinitis, is worth the clinical promotion.