CAJ | 학술논문

目的：探讨晚期非小细胞肺癌患者常规化疗与常规化疗联合抗抑郁治疗生活质量、化疗疗效的差异。方法将符合纳入标准的39例患者按简单随机方法分为治疗组（19例）和对照组（20例），治疗组给予常规化疗加抗抑郁治疗，对照组仅给予常规化疗，所有患者在治疗前、中、后给予卡式评分及抑郁评估，采用 Karnofsky 功能状态量表（KPS）进行行为状态评估，采用Zung抑郁自评量表（SDS）进行抑郁评估，同时采用 WHO实体瘤疗效评估标准进行化疗疗效评价。结果治疗组治疗中及治疗后的KPS评分高于对照组（P＜0．05），且治疗组化疗疗效优于对照组（P＜0．05）。结论抗抑郁治疗可提高晚期肺癌患者生活质量和化疗疗效。
목적：탐토만기비소세포폐암환자상규화료여상규화료연합항억욱치료생활질량、화료료효적차이。방법장부합납입표준적39례환자안간단수궤방법분위치료조（19례）화대조조（20례），치료조급여상규화료가항억욱치료，대조조부급여상규화료，소유환자재치료전、중、후급여잡식평분급억욱평고，채용 Karnofsky 공능상태량표（KPS）진행행위상태평고，채용Zung억욱자평량표（SDS）진행억욱평고，동시채용 WHO실체류료효평고표준진행화료료효평개。결과치료조치료중급치료후적KPS평분고우대조조（P＜0．05），차치료조화료료효우우대조조（P＜0．05）。결론항억욱치료가제고만기폐암환자생활질량화화료료효。
ABSTRACT:Objective To compare the effects of conventional chemotherapy and conventional chemotherapy combined with antidepressant therapy on the quality of life and chemotherapeutic efficacy in patients with advanced non-small-cell lung cancer(NSCLC).Methods Patients meet-ing inclusion criteria were randomly treated with conventional chemotherapy alone(control group) or in combination with antidepressant therapy(treatment group).Before,during and after treat-ment,the performance status,depression and chemotherapeutic efficacy were assessed using Karnofsky Performance Status Scale (KPS),Zung Self-Rating Depression Scale (SDS)and Re-sponse Evaluation Criteria in Solid Tumors(RECIST),respectively.Results Compared with con-trol group,KPS score was increased and chemotherapeutic efficacy was improved in treatment group during and after treatment(P<0.05).Conclusion Antidepressant therapy can improves the quality of life and chemotherapeutic efficacy in patients with advanced NSCLC.