CAJ | 학술논문

目的：探讨氟比洛芬酯用于原发性淋巴水肿下肢吸脂术后的镇痛效果。方法2012年11月～2014年9月选择全麻下肢吸脂60例，按照手术先后顺序分为A、B、C组（每组20例），手术结束前10～20 min，A组不给予任何止痛药物， B组静注帕瑞昔布钠40 mg，C组静注氟比洛芬酯100 mg。观察术后1、2、6、12、24 h的VAS和术后不良反应。结果与A组相比，B组静息痛和运动痛术后1、2、6、12 h VAS显著降低（P＜0．05），C组静息痛和运动痛术后1、2、12 h VAS显著降低（P＜0．05）。 B组和C组术后1、2 h静息痛和运动痛VAS差异无统计学意义（P＞0．05），6、12 h VAS差异有统计学意义（P＜0.05）。3组术后24 h静息痛和运动痛VAS差异无统计学意义（ P＞0．05）。3组患者恶心呕吐、头疼头晕发生率比较无统计学差异（ P＞0．05）。结论原发性淋巴水肿下肢吸脂术使用氟比洛芬酯和帕瑞昔布钠均能取得较好的术后镇痛效果。
목적：탐토불비락분지용우원발성림파수종하지흡지술후적진통효과。방법2012년11월～2014년9월선택전마하지흡지60례，안조수술선후순서분위A、B、C조（매조20례），수술결속전10～20 min，A조불급여임하지통약물， B조정주파서석포납40 mg，C조정주불비락분지100 mg。관찰술후1、2、6、12、24 h적VAS화술후불량반응。결과여A조상비，B조정식통화운동통술후1、2、6、12 h VAS현저강저（P＜0．05），C조정식통화운동통술후1、2、12 h VAS현저강저（P＜0．05）。 B조화C조술후1、2 h정식통화운동통VAS차이무통계학의의（P＞0．05），6、12 h VAS차이유통계학의의（P＜0.05）。3조술후24 h정식통화운동통VAS차이무통계학의의（ P＞0．05）。3조환자악심구토、두동두훈발생솔비교무통계학차이（ P＞0．05）。결론원발성림파수종하지흡지술사용불비락분지화파서석포납균능취득교호적술후진통효과。
Objective To investigate analgesic effects of flurbiprofen in lower extremity liposuction for patients with primary lymphedema. Methods A total of 60 patients receiving lower extremity liposuction under general anesthesia were allocated to 3 groups:the control group (group A) received no analgesic drug 10-20 min before the end of operation, the parecoxib group (group B) received intravenous parecoxib 40 mg, and the flurbiprofen group (group C) received intravenous flurbiprofen 100 mg.The VAS was recorded at 1, 2, 6, 12, and 24 h after operation.Adverse reactions were also recorded . Results The VAS of rest pain and motion pain at 1, 2, 6, and 12 h were significantly lower in the group B than those in the group A (P<0.05);the VAS of rest pain and motion pain at 1, 2, and 12 h were significantly lower in the group C than those in the group A (P<0.05).The VAS at 1 and 2 h did not differ between the group B and C (P>0.05), but had significant difference at 6 and 12 h (P<0.05).No significant differences in the VAS at 24 h were observed among the three groups (P>0.05).Adverse reactions were not different among the three groups (P>0.05). Conclusion Both flurbiprofen and parecoxib sodium can achieve good postoperative analgesic effects in patients with lymphedema receiving lower extremity liposuction .