广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2015年
11期
54-55,67
,共3页
任佳%袁燕%张秀玲%黄益蝶%胡锦涛%吴家守
任佳%袁燕%張秀玲%黃益蝶%鬍錦濤%吳傢守
임가%원연%장수령%황익접%호금도%오가수
二吲哚甲烷%水相%催化%十二烷基磺酸钠%盐酸
二吲哚甲烷%水相%催化%十二烷基磺痠鈉%鹽痠
이신타갑완%수상%최화%십이완기광산납%염산
bis(indolyl)methanes%aqueous media%catalyse%sodium dodecyl sulfonate%hydrochloric acid
二吲哚甲烷及其衍生物是很多生理活性分子的重要构成部分,我们开发了一种新的合成二吲哚甲烷及其衍生物的方法。在10mol%的十二烷基苯磺酸钠和盐酸的共同催化下,吲哚和醛、酮在60℃下能顺利、高效的发生反应得到二吲哚甲烷衍生物。在最优的反应条件下,我们对醛和酮的适用范围进行了考察。催化剂循环使用研究表明,该催化体系在循环使用五次后仍能保持很好的催化活性。
二吲哚甲烷及其衍生物是很多生理活性分子的重要構成部分,我們開髮瞭一種新的閤成二吲哚甲烷及其衍生物的方法。在10mol%的十二烷基苯磺痠鈉和鹽痠的共同催化下,吲哚和醛、酮在60℃下能順利、高效的髮生反應得到二吲哚甲烷衍生物。在最優的反應條件下,我們對醛和酮的適用範圍進行瞭攷察。催化劑循環使用研究錶明,該催化體繫在循環使用五次後仍能保持很好的催化活性。
이신타갑완급기연생물시흔다생리활성분자적중요구성부분,아문개발료일충신적합성이신타갑완급기연생물적방법。재10mol%적십이완기분광산납화염산적공동최화하,신타화철、동재60℃하능순리、고효적발생반응득도이신타갑완연생물。재최우적반응조건하,아문대철화동적괄용범위진행료고찰。최화제순배사용연구표명,해최화체계재순배사용오차후잉능보지흔호적최화활성。
Bis(indolyl)methanes are important building units found in numerous natural and unnatural biologically molecules. A new catalytic system to bis(indolyl) methanes was developed. Rapid and highly efficient synthesis of bis (indolyl)methanes was achieved by the condensation of indole and aldehydes/ ketones in water in the presence of 10mol%sodium dodecyl sulfonate and 10mol% HCl at 60 ℃ . The substrate scope was investigated under the optimal reaction conditions. The possibility of recovery and reusability of the catalytic system was also investigated. The catalytic system can be recycled at least five times with little loss in yield on the 6th run.