CAJ | 학술논문

3位取代的吲哚是很多生理活性分子的重要构成部分，我们开发了一种新的合成3-取代吲哚衍生物的方法。在无溶剂条件下，以20mol%的吡啶盐酸盐为催化剂，反应温度为100℃时，吲哚能顺利地和查尔酮类化合物发生迈克尔加成反应得到相应的3-取代吲哚衍生物。我们用不同取代的查尔酮类化合物对底物的适用范围进行考察，结果表明方法适用范围较广，收率最高可达87%。
3위취대적신타시흔다생리활성분자적중요구성부분，아문개발료일충신적합성3-취대신타연생물적방법。재무용제조건하，이20mol%적필정염산염위최화제，반응온도위100℃시，신타능순리지화사이동류화합물발생매극이가성반응득도상응적3-취대신타연생물。아문용불동취대적사이동류화합물대저물적괄용범위진행고찰，결과표명방법괄용범위교엄，수솔최고가체87%。
3-substituted indoles are important building units found in numerous natural and unnatural biologically molecules. A new catalytic system to 3-substituted indoles was developed. The Michael addition reaction of indole with chalcones proceeded smoothly to give the corresponding 3 - substituted indoles catalyzed by 20mol% of pyridine hydrochloride at 100 ℃ under solventless condition. Chalcones with different substituents reacted smoothly with indole under the optimal reaction conditions giving 3-substituted indoles up to 87% yield.