目的 探讨超低位直肠癌保肛术的临床应用价值.方法 回顾性分析2009年1月至2013年9月皖南医学院弋矶山医院收治的226例超低位直肠癌患者的临床资料.117例患者行超低位直肠癌保肛术设为保肛组,109例患者行腹会阴联合直肠癌根治术设对照组.保肛组行直肠低位前切除术或改良直肠低位前切除术;对照组行常规腹会阴联合直肠癌根治术.分析两组患者手术时间、术中出血量、术中清扫淋巴结数目、肠道功能恢复时间以及术后短期并发症、局部肿瘤复发、远处转移、生存率及生命质量.计数资料采用x2检验,正态分布的计量资料以哥(x)±s表示,采用t检验,采用Kaplan-Meier法计算生存率,Logrank检验进行生存分析.采用定期门诊和电话进行随访,随访时间截至2014年9月.结果 117例保肛组患者行传统的直肠低位前切除术108例,直肠翻转肛门内拖出切割缝合改良直肠低位前切除术9例;109例对照组患者均行腹会阴联合直肠癌根治术.保肛组患者的手术时间及术中出血量分别为(117±12)min、(110±51)mL,与对照组患者的(122±8)min和(155 ±44) mL比较,差异有统计学意义(t=3.80,7.09,P<0.05).保肛组和对照组患者术中清扫淋巴结数目和肠道功能恢复时间分别为(13±4)枚和(13±4)枚、(2.8±0.8)d和(2.7 ±0.7)d,两组比较,差异均无统计学意义(t=0.90,0.83,P>0.05).术后184例患者行化疗,其中19例因化疗反应严重终止治疗,17例化疗结束后继续放疗,9例化疗结束后继续行肝脏介入治疗;42例患者未行化疗.保肛组患者肛周湿疹的发生率为15.38% (18/117)较对照组3.67%(4/109)明显增高(x2=8.81,P<0.05).保肛组和对照组发生吻合口漏、腹腔内出血、腹腔内感染、术后尿潴留、切口感染、切口裂开的患者例数分别为4例和0、3例和2例、5例和4例、10例和11例、7例和8例、9例和5例,两组比较,差异无统计学意义(x2=1.86,0.14,0.05,0.16,0.19,0.94,P>0.05).190例患者获得随访,中位随访时间为34.5个月(12.0~ 57.0个月).保肛组与对照组患者术后肿瘤的局部复发率、远处转移率、1、3年生存率分别为8.55%(10/117)和8.26%(9/109)、5.98%(7/117)和5.50%(6/109)、94.8%和95.7%、76.2%和76.1%,两组比较,差异均无统计学意义(x2=0.01,0.02,0.08,0.00,P>0.05).保肛组患者生命质量评分为(66±14)分,高于对照组的(49±11)分,两组比较,差异有统计学意义(t=10.13,P<0.05).结论 严格把握手适应证,超低位直肠癌保肛术安全可行,能够改善患者术后的生命质量.
目的 探討超低位直腸癌保肛術的臨床應用價值.方法 迴顧性分析2009年1月至2013年9月皖南醫學院弋磯山醫院收治的226例超低位直腸癌患者的臨床資料.117例患者行超低位直腸癌保肛術設為保肛組,109例患者行腹會陰聯閤直腸癌根治術設對照組.保肛組行直腸低位前切除術或改良直腸低位前切除術;對照組行常規腹會陰聯閤直腸癌根治術.分析兩組患者手術時間、術中齣血量、術中清掃淋巴結數目、腸道功能恢複時間以及術後短期併髮癥、跼部腫瘤複髮、遠處轉移、生存率及生命質量.計數資料採用x2檢驗,正態分佈的計量資料以哥(x)±s錶示,採用t檢驗,採用Kaplan-Meier法計算生存率,Logrank檢驗進行生存分析.採用定期門診和電話進行隨訪,隨訪時間截至2014年9月.結果 117例保肛組患者行傳統的直腸低位前切除術108例,直腸翻轉肛門內拖齣切割縫閤改良直腸低位前切除術9例;109例對照組患者均行腹會陰聯閤直腸癌根治術.保肛組患者的手術時間及術中齣血量分彆為(117±12)min、(110±51)mL,與對照組患者的(122±8)min和(155 ±44) mL比較,差異有統計學意義(t=3.80,7.09,P<0.05).保肛組和對照組患者術中清掃淋巴結數目和腸道功能恢複時間分彆為(13±4)枚和(13±4)枚、(2.8±0.8)d和(2.7 ±0.7)d,兩組比較,差異均無統計學意義(t=0.90,0.83,P>0.05).術後184例患者行化療,其中19例因化療反應嚴重終止治療,17例化療結束後繼續放療,9例化療結束後繼續行肝髒介入治療;42例患者未行化療.保肛組患者肛週濕疹的髮生率為15.38% (18/117)較對照組3.67%(4/109)明顯增高(x2=8.81,P<0.05).保肛組和對照組髮生吻閤口漏、腹腔內齣血、腹腔內感染、術後尿潴留、切口感染、切口裂開的患者例數分彆為4例和0、3例和2例、5例和4例、10例和11例、7例和8例、9例和5例,兩組比較,差異無統計學意義(x2=1.86,0.14,0.05,0.16,0.19,0.94,P>0.05).190例患者穫得隨訪,中位隨訪時間為34.5箇月(12.0~ 57.0箇月).保肛組與對照組患者術後腫瘤的跼部複髮率、遠處轉移率、1、3年生存率分彆為8.55%(10/117)和8.26%(9/109)、5.98%(7/117)和5.50%(6/109)、94.8%和95.7%、76.2%和76.1%,兩組比較,差異均無統計學意義(x2=0.01,0.02,0.08,0.00,P>0.05).保肛組患者生命質量評分為(66±14)分,高于對照組的(49±11)分,兩組比較,差異有統計學意義(t=10.13,P<0.05).結論 嚴格把握手適應證,超低位直腸癌保肛術安全可行,能夠改善患者術後的生命質量.
목적 탐토초저위직장암보항술적림상응용개치.방법 회고성분석2009년1월지2013년9월환남의학원익기산의원수치적226례초저위직장암환자적림상자료.117례환자행초저위직장암보항술설위보항조,109례환자행복회음연합직장암근치술설대조조.보항조행직장저위전절제술혹개량직장저위전절제술;대조조행상규복회음연합직장암근치술.분석량조환자수술시간、술중출혈량、술중청소림파결수목、장도공능회복시간이급술후단기병발증、국부종류복발、원처전이、생존솔급생명질량.계수자료채용x2검험,정태분포적계량자료이가(x)±s표시,채용t검험,채용Kaplan-Meier법계산생존솔,Logrank검험진행생존분석.채용정기문진화전화진행수방,수방시간절지2014년9월.결과 117례보항조환자행전통적직장저위전절제술108례,직장번전항문내타출절할봉합개량직장저위전절제술9례;109례대조조환자균행복회음연합직장암근치술.보항조환자적수술시간급술중출혈량분별위(117±12)min、(110±51)mL,여대조조환자적(122±8)min화(155 ±44) mL비교,차이유통계학의의(t=3.80,7.09,P<0.05).보항조화대조조환자술중청소림파결수목화장도공능회복시간분별위(13±4)매화(13±4)매、(2.8±0.8)d화(2.7 ±0.7)d,량조비교,차이균무통계학의의(t=0.90,0.83,P>0.05).술후184례환자행화료,기중19례인화료반응엄중종지치료,17례화료결속후계속방료,9례화료결속후계속행간장개입치료;42례환자미행화료.보항조환자항주습진적발생솔위15.38% (18/117)교대조조3.67%(4/109)명현증고(x2=8.81,P<0.05).보항조화대조조발생문합구루、복강내출혈、복강내감염、술후뇨저류、절구감염、절구렬개적환자례수분별위4례화0、3례화2례、5례화4례、10례화11례、7례화8례、9례화5례,량조비교,차이무통계학의의(x2=1.86,0.14,0.05,0.16,0.19,0.94,P>0.05).190례환자획득수방,중위수방시간위34.5개월(12.0~ 57.0개월).보항조여대조조환자술후종류적국부복발솔、원처전이솔、1、3년생존솔분별위8.55%(10/117)화8.26%(9/109)、5.98%(7/117)화5.50%(6/109)、94.8%화95.7%、76.2%화76.1%,량조비교,차이균무통계학의의(x2=0.01,0.02,0.08,0.00,P>0.05).보항조환자생명질량평분위(66±14)분,고우대조조적(49±11)분,량조비교,차이유통계학의의(t=10.13,P<0.05).결론 엄격파악수괄응증,초저위직장암보항술안전가행,능구개선환자술후적생명질량.
Objective To investigate the clinical value of anus-preserving operation for ultra low rectal cancer.Methods The clinical data of 226 patients with ultra low rectal cancer who were admitted to the Yijishan Hospital between January 2009 and September 2013 were retrospectively analyzed.All the patients were divided into the anus-preserving group (117 patients underwent traditional or modified Dixon operation) and the control group (109 patients underwent Miles operation).The operation time,volume of intraoperative blood loss,number of lymph node dissection,recovery time of intestinal function,postoperative short-term amplications,local recurrence and distal metastasis of tumors,survival rate and quality of life in the 2 groups were analyzed.The measurement data with normal distribution were presented as (x) ± s and analyzed using t test,count data were analyzed using Pearson chi-square test.The survival curve was drawn by Kaplan-Meier method,and the survival rate was analyzed using the Log-rank test.The patients were followed up by regular out-patient examination and telephone interview up to September 2014.Results The traditional Dixon operation was performed on 108 patients,modified Dixon operation on 9 patients and Miles operation on 109 patients in the control group.The operation time and volume of blood loss were (117 ± 12) minutes and (110 ± 51) mL in the anus-preserving group,which were significantly different from (122 ± 8) minutes and (155 ± 44) mL in the control group (t =3.80,7.09,P < 0.05).The number of lymph node dissected and time of intestinal function recovery were 13 ±4 and (2.8 ± 0.8)days in the anus-preserving group and 13 ±4 and (2.7 ± 0.7)days in the control group,respectively,with no significant difference (t =0.90,0.83,P > 0.05).Among the 184 patients receiving postoperative chemotherapy,19 patients terminated the chemotherapy due to serious response to chemotherapy,17 patients received radiotherapy after chemotherapy,9 patients received interventional treatment for liver after chemotherapy and 42 patients didn't receive the chemotherapy.The incidence of perianal eczema were 15.38% (18/117) in the anus-preserving group and 3.67% (4/109) in the control group,with a significant difference between the 2 groups (x2=8.81,P <0.05).The cases of anastomotic leakage,intra-abdominal bleeding,intra-abdominal infection,postoperative urinary retention,infection of incision and incision dehiscence were 4,3,5,10,7 and 9 in the anus-preserving group,which were not significantly different from 0,2,4,11,8 and 5 in the control group (x2=1.86,0.14,0.05,0.16,0.19,0.94,P > 0.05).One-hundred and ninety patients were followed up for a median time of 34.5 months (range,12.0-57.0 months).The rate of local tumor recurrence,rate of distant metastasis and 1-and 3-year survival rate were 8.55% (10/117),5.98% (7/117),94.8% and 76.2% in the anus-preserving group and 8.26% (9/109),5.50% (6/109),95.7% and 76.1% in the control group,with no significant difference between the 2 groups (x2 =0.01,0.02,0.08,0.00,P > 0.05).The score of life quality was 66 ± 14 in the anus-preserving group,which was significantly higher than 49 ± 11 in the control group (t =10.13,P < 0.05).Conclusion The anus-preserving operation for ultra low rectal cancer is safe and feasible based on strictly grasping operative indications,meanwhile,it can improve the postoperative life quality of patients.