CAJ | 학술논문

目的：评估预防接种后发生急性播散性脑脊髓炎（ADEM）的风险。方法以2011—2013年各类疫苗的接种人次数作为观察例数，以2008—2010年广东省 ADEM 流行病学调查获得的年龄组发病率作为发生概率，采用 Poisson 分布的单侧累计概率函数，计算预防接种后 ADEM 发病的 Poisson 分布的单侧累计概率，评估2011—2013年全省预防接种后发生 ADEM 的风险。结果2011—2013年全省人群不同疫苗预防接种后 ADEM发病8例；各年度各类疫苗接种后 ADEM 发病单侧累计概率在0.6849～0.9993之间。结论2011—2013年预防接种后的人群 ADEM 发病率与一般人群比较差异无统计学意义，预防接种未增加 ADEM 的发病风险。
목적：평고예방접충후발생급성파산성뇌척수염（ADEM）적풍험。방법이2011—2013년각류역묘적접충인차수작위관찰례수，이2008—2010년광동성 ADEM 류행병학조사획득적년령조발병솔작위발생개솔，채용 Poisson 분포적단측루계개솔함수，계산예방접충후 ADEM 발병적 Poisson 분포적단측루계개솔，평고2011—2013년전성예방접충후발생 ADEM 적풍험。결과2011—2013년전성인군불동역묘예방접충후 ADEM발병8례；각년도각류역묘접충후 ADEM 발병단측루계개솔재0.6849～0.9993지간。결론2011—2013년예방접충후적인군 ADEM 발병솔여일반인군비교차이무통계학의의，예방접충미증가 ADEM 적발병풍험。
Objective To assess the risk of the acute disseminated encephalomyelitis(ADEM)after vaccination. Methods Based on the vaccinated population from 2011 to 2013,the incidences of ADEM among different age groups from 2008 to 2010 obtained from epidemiological investigation in Guangdong province were taken as control,one - tailed cumulative probability of Poisson distribution was calculated to assess the risk of ADEM after vaccination in Guangdong Province during 2011 - 2013. Results There were eight ADEM cases among vaccination population in Guangdong Prov-ince during 2011 - 2013. The one - tailed cumulative probability of the occurrence of ADEM after vaccination each year varied from 0. 684 9 to 0. 999 3. Conclusion There is no statistically significant difference in ADEM incidence between those who received vaccination and the general population from 2011 to 2013 in Guangdong Province,suggesting vaccina-tion doesn't increase the risk of ADEM.