中西医结合研究
中西醫結閤研究
중서의결합연구
RESEARCH OF INTEGRATED TRADITIONAL CHINESE AND WESTERN MEDICINE
2015年
2期
60-62
,共3页
复方苦参注射液%晚期乳腺癌%姑息治疗
複方苦參註射液%晚期乳腺癌%姑息治療
복방고삼주사액%만기유선암%고식치료
compound matrine injection%advanced breast cancer%palliative treatment
目的:观察复方苦参注射液在晚期乳腺癌姑息治疗中的临床疗效。方法选取无法耐受化疗的术后转移的晚期乳腺癌患者30例,随机分为2组,每组15例。对照组采用单纯支持治疗,合并胸腔积液者采用胸腔穿刺抽液治疗;治疗组采用静脉滴注复方苦参注射液加支持治疗,合并胸腔积液者采用胸腔穿刺抽液加注入复方苦参注射液治疗;比较2组疼痛缓解程度、体力状况改变、近期疗效、毒副反应及生存期。结果①对照组疼痛缓解率为53.3%,治疗组为86.7%,2组比较差异有统计学意义(P<0.05);②对照组体力状况改善率为13.3%,治疗组为53.3%,2组比较差异有统计学意义(P<0.05);③近期疗效2组均无CR、PR者,对照组稳定率为40.0%,治疗组稳定率为80.0%,2组比较差异有统计学意义(P<0.05);④对照组中位生存期为4.9个月,治疗组为5.5个月,2组比较差异无统计学意义( P>0.05)。结论复方苦参注射液姑息治疗晚期乳腺癌,具有减轻疼痛,提高患者生活质量的作用,且无明显毒副作用。
目的:觀察複方苦參註射液在晚期乳腺癌姑息治療中的臨床療效。方法選取無法耐受化療的術後轉移的晚期乳腺癌患者30例,隨機分為2組,每組15例。對照組採用單純支持治療,閤併胸腔積液者採用胸腔穿刺抽液治療;治療組採用靜脈滴註複方苦參註射液加支持治療,閤併胸腔積液者採用胸腔穿刺抽液加註入複方苦參註射液治療;比較2組疼痛緩解程度、體力狀況改變、近期療效、毒副反應及生存期。結果①對照組疼痛緩解率為53.3%,治療組為86.7%,2組比較差異有統計學意義(P<0.05);②對照組體力狀況改善率為13.3%,治療組為53.3%,2組比較差異有統計學意義(P<0.05);③近期療效2組均無CR、PR者,對照組穩定率為40.0%,治療組穩定率為80.0%,2組比較差異有統計學意義(P<0.05);④對照組中位生存期為4.9箇月,治療組為5.5箇月,2組比較差異無統計學意義( P>0.05)。結論複方苦參註射液姑息治療晚期乳腺癌,具有減輕疼痛,提高患者生活質量的作用,且無明顯毒副作用。
목적:관찰복방고삼주사액재만기유선암고식치료중적림상료효。방법선취무법내수화료적술후전이적만기유선암환자30례,수궤분위2조,매조15례。대조조채용단순지지치료,합병흉강적액자채용흉강천자추액치료;치료조채용정맥적주복방고삼주사액가지지치료,합병흉강적액자채용흉강천자추액가주입복방고삼주사액치료;비교2조동통완해정도、체력상황개변、근기료효、독부반응급생존기。결과①대조조동통완해솔위53.3%,치료조위86.7%,2조비교차이유통계학의의(P<0.05);②대조조체력상황개선솔위13.3%,치료조위53.3%,2조비교차이유통계학의의(P<0.05);③근기료효2조균무CR、PR자,대조조은정솔위40.0%,치료조은정솔위80.0%,2조비교차이유통계학의의(P<0.05);④대조조중위생존기위4.9개월,치료조위5.5개월,2조비교차이무통계학의의( P>0.05)。결론복방고삼주사액고식치료만기유선암,구유감경동통,제고환자생활질량적작용,차무명현독부작용。
Objective To observe the clinical efficacy of compound matrine injection in the palliative treatment of advanced breast cancer. Methods 30 cases postoperative metastatic breast cancer patients ,w ho w ere unable to tolerate chemotherapy ,were randomly divided into two groups ,15 cases in each group. The patients in control group were given simple support treatment ,and pleural puncture and drainage therapy was given if with pleural ef‐fusion. The patients in treatment group were treated with intravenous infusion of compound matrine injection based on the support treatment ,and intrapleural injection of compound matrine was given if with pleural effusion. To ob‐serve the degree of pain relief ,the change of physical condition ,the recent curative effect ,adverse reaction ,and sur‐vival time.Results ① The pain relief rate was 53.3% in the control group ,which in the treatment group was 86.7% ,there was significant difference between the two groups(P< 0.05);② The improvement rate of physical condition in control group was 13.3% ,and which in the treatment group was 53.3% ,there was significant differ‐ence between the two groups(P<0.05);③ There had no CR and PR in the two groups ,but stable rate in control group was 40.0% ,and which in treatment group was 80.0% ,there was significant differences between the two groups(P<0.05);④The median survival time was 4.9 months in control group ,and which in treatment group was 5.5 months ,there had no significant difference between the two groups(P>0.05).Conclusion Compound matrine injection can relieve pain ,improve the quality of life of patients ,and no apparent side effects in palliative treatment of advanced breast cancer.