高等学校化学学报
高等學校化學學報
고등학교화학학보
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES
2015年
6期
1100-1106
,共7页
刘丹%胡秀芳%郑艳艳%潘鹤%罗舒维%洪芳%赵文娜%姜美红%祝云辉%邵敬伟%王文峰
劉丹%鬍秀芳%鄭豔豔%潘鶴%囉舒維%洪芳%趙文娜%薑美紅%祝雲輝%邵敬偉%王文峰
류단%호수방%정염염%반학%라서유%홍방%조문나%강미홍%축운휘%소경위%왕문봉
大黄素%芦荟大黄素%亲脂性阳离子%抗癌活性
大黃素%蘆薈大黃素%親脂性暘離子%抗癌活性
대황소%호회대황소%친지성양리자%항암활성
Emodin%Aloe emodin%Lipiophilic cation%Anticancer activity
合成了7个大黄素季铵盐、2个芦荟大黄素季铵盐、1个水溶性大黄素季铵盐和1个α-萘酚醌苯基甲烷季铵盐化合物，并测试了其抗癌活性。含有1条长碳链的大黄素季铵盐的抗癌活性很低，但是含有2条长碳链的大黄素和芦荟大黄素季铵盐的抗癌活性较好。用亲水性的长链替代季铵盐中亲脂性的长碳链会导致大黄素季铵盐失去抗癌活性。α-萘酚醌苯基甲烷季铵盐显示了中等的抗癌活性，表明在具有电子传递能力的分子中引入亲脂性的长碳链季铵盐可以增加其抗癌活性。
閤成瞭7箇大黃素季銨鹽、2箇蘆薈大黃素季銨鹽、1箇水溶性大黃素季銨鹽和1箇α-萘酚醌苯基甲烷季銨鹽化閤物，併測試瞭其抗癌活性。含有1條長碳鏈的大黃素季銨鹽的抗癌活性很低，但是含有2條長碳鏈的大黃素和蘆薈大黃素季銨鹽的抗癌活性較好。用親水性的長鏈替代季銨鹽中親脂性的長碳鏈會導緻大黃素季銨鹽失去抗癌活性。α-萘酚醌苯基甲烷季銨鹽顯示瞭中等的抗癌活性，錶明在具有電子傳遞能力的分子中引入親脂性的長碳鏈季銨鹽可以增加其抗癌活性。
합성료7개대황소계안염、2개호회대황소계안염、1개수용성대황소계안염화1개α-내분곤분기갑완계안염화합물，병측시료기항암활성。함유1조장탄련적대황소계안염적항암활성흔저，단시함유2조장탄련적대황소화호회대황소계안염적항암활성교호。용친수성적장련체대계안염중친지성적장탄련회도치대황소계안염실거항암활성。α-내분곤분기갑완계안염현시료중등적항암활성，표명재구유전자전체능력적분자중인입친지성적장탄련계안염가이증가기항암활성。
Seven emodin quaternary ammonium salts, two aloe emodin quaternary ammonium salts, one water soluble emodin quaternary ammonium as well as a quaternary ammonium salt of α-naphtholbenzein were syn-thesized and the in vitro anticancer activities were tested. Emodin quaternary ammonium salts containing one long carbon chain showed very low anticancer activities, and emodin and aloe emodin quaternary ammonium salts containing two carbon chains exhibited high anticancer activities. Using hydrophilic long chains to replace lipiophilic long carbon chains made emodin quaternary ammonium salts lose anticancer activities. Quaternary ammonium salt ofα-naphtholbenzein showed a moderate anticancer activity, which indicated that the introduc-tion of lipiophilic cations to a molecule with ability to transfer electrons could increase its anticancer activity.
