中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
12期
34-35,36
,共3页
左乙拉西坦%神经外科术后癫痫%发作频率%脑电图
左乙拉西坦%神經外科術後癲癇%髮作頻率%腦電圖
좌을랍서탄%신경외과술후전간%발작빈솔%뇌전도
levetiracetam%epilepsy after neurosurgical operation%seizure frequency%EEG
目的：探讨左乙拉西坦治疗神经外科术后癫痫的疗效。方法将102例术后癫痫患者随机分为对照组和观察组，各51例。对照组患者采用传统抗癫痫药物丙戊酸钠治疗，观察组患者使用左乙拉西坦。观察并比较两组患者治疗后发作频率降低情况及总有效率的差异，以及治疗前后脑电图（EEG）变化情况。记录两组患者治疗过程中药品相关不良反应发生情况。结果对照组患者发作频率降低百分比及总有效率显著低于观察组（68.63%比82.35%，P<0.05）；两组患者EEG变化情况无明显差异（47.06%比51.02%，P ？0.05）；两组患者治疗后SF－36评分均较治疗前显著增高（ P<0.05），且观察组一般健康状况（GH）、精力（VT）、社会功能（SF）3项指标较对照组显著增高（ P<0.05）；两组患者药品不良反应发生情况未见明显差异。结论左乙拉西坦治疗神经外科术后癫痫疗效确切，过程安全。
目的：探討左乙拉西坦治療神經外科術後癲癇的療效。方法將102例術後癲癇患者隨機分為對照組和觀察組，各51例。對照組患者採用傳統抗癲癇藥物丙戊痠鈉治療，觀察組患者使用左乙拉西坦。觀察併比較兩組患者治療後髮作頻率降低情況及總有效率的差異，以及治療前後腦電圖（EEG）變化情況。記錄兩組患者治療過程中藥品相關不良反應髮生情況。結果對照組患者髮作頻率降低百分比及總有效率顯著低于觀察組（68.63%比82.35%，P<0.05）；兩組患者EEG變化情況無明顯差異（47.06%比51.02%，P ？0.05）；兩組患者治療後SF－36評分均較治療前顯著增高（ P<0.05），且觀察組一般健康狀況（GH）、精力（VT）、社會功能（SF）3項指標較對照組顯著增高（ P<0.05）；兩組患者藥品不良反應髮生情況未見明顯差異。結論左乙拉西坦治療神經外科術後癲癇療效確切，過程安全。
목적：탐토좌을랍서탄치료신경외과술후전간적료효。방법장102례술후전간환자수궤분위대조조화관찰조，각51례。대조조환자채용전통항전간약물병무산납치료，관찰조환자사용좌을랍서탄。관찰병비교량조환자치료후발작빈솔강저정황급총유효솔적차이，이급치료전후뇌전도（EEG）변화정황。기록량조환자치료과정중약품상관불량반응발생정황。결과대조조환자발작빈솔강저백분비급총유효솔현저저우관찰조（68.63%비82.35%，P<0.05）；량조환자EEG변화정황무명현차이（47.06%비51.02%，P ？0.05）；량조환자치료후SF－36평분균교치료전현저증고（ P<0.05），차관찰조일반건강상황（GH）、정력（VT）、사회공능（SF）3항지표교대조조현저증고（ P<0.05）；량조환자약품불량반응발생정황미견명현차이。결론좌을랍서탄치료신경외과술후전간료효학절，과정안전。
Objective To investigate the efficacy of levetiracetam in treating epilepsy after neurosurgical operation. Methods Totally 102 cases of postoperative epilepsy were randomly divided into the control group and the observation group,51 cases in each group. The control group was treated by the traditional antiepileptic drug sodium valproate treatment,while the observation group used the antiepileptic drug levetiracetam. The decrease situation of seizure frequency,total effective rate and EEG after treatment were observed and compared between the two groups. In addition,the occurrence situation of adverse reactions during the treatment process was ob-served in the two groups. Results The decrease percentage of seizure frequency and the total effective rate in the control group were significantly lower than those in the observation group,the differences were statistically significant(68. 63% vs 82. 35%,P < 0. 05);the EEG change situation had no significant difference between the two groups(47. 06% vs 51. 02%,P ? 0. 05);the SF-36 score after treatment in the two groups were significantly increased compared with before treatment( P < 0. 05),moreover the observation group was sig-nificantly increased than the control group in the aspects of the general health status(GH),vigour(VT)and social function(SF)(P < 0. 05). The occurrence rate of adverse reactions had no statistically significantly difference between the two groups. Conclusion Levetiracetam is definitely effective and safe for treating epilepsy after neurosurgical operation with safe process.
