CAJ | 학술논문

目的：探讨子宫动脉介入化学治疗(简称化疗)对宫颈癌患者的临床疗效及预后影响。方法将82例宫颈癌Ⅱb期患者随机分为对照组和观察组，各41例。对照组患者采用传统全身静脉滴注化疗，观察组患者在对照组药物剂量、疗程不变的基础上采用介入技术将卡铂经子宫动脉直接灌注。结果对照组患者的总有效率为48.78%，显著低于观察组的75.61%（ P<0.05）；对照组患者的手术时间长于观察组，切缘残留阳性率、术后并发症发生率均显著高于观察组（ P<0.05），术中出血量、术后尿管留置时间两组间未见明显差异（ P ？0.05）；化疗后，两组均有病理组织学转化为Ⅰ级和Ⅱ级的病例，观察组该指标改善更明显（ P<0.05）；远期随访结果显示，观察组患者的3年及5年生存率均显著高于对照组患者（ P<0.05）；观察组的不良反应明显轻于对照组。结论子宫动脉介入化疗治疗宫颈癌疗效确切，远期生存率及预后较传统化疗方法好。
목적：탐토자궁동맥개입화학치료(간칭화료)대궁경암환자적림상료효급예후영향。방법장82례궁경암Ⅱb기환자수궤분위대조조화관찰조，각41례。대조조환자채용전통전신정맥적주화료，관찰조환자재대조조약물제량、료정불변적기출상채용개입기술장잡박경자궁동맥직접관주。결과대조조환자적총유효솔위48.78%，현저저우관찰조적75.61%（ P<0.05）；대조조환자적수술시간장우관찰조，절연잔류양성솔、술후병발증발생솔균현저고우관찰조（ P<0.05），술중출혈량、술후뇨관류치시간량조간미견명현차이（ P ？0.05）；화료후，량조균유병리조직학전화위Ⅰ급화Ⅱ급적병례，관찰조해지표개선경명현（ P<0.05）；원기수방결과현시，관찰조환자적3년급5년생존솔균현저고우대조조환자（ P<0.05）；관찰조적불량반응명현경우대조조。결론자궁동맥개입화료치료궁경암료효학절，원기생존솔급예후교전통화료방법호。
Objective To investigate the effect of uterine artery interventional chemotherapy in treating patients with cervical cancer and its influence on prognosis. Methods 82 cases of stage Ⅱb cervical cancer were randomly divided into the control group and the ob-servation group,41 cases in each group. The control group used the traditional systemic intravenous drip of chemotherapy,while on the basis of unchanged dose and treatment course the patients in the observation group adopted the intervention technique of administration route for directly perfusing paraplatin via the uterine artery. Results The total treatment effective rate of the control group was signifi-cantly lower than that of the observation group(48. 78% vs 75. 61%);the operation time of the control group was longer than that in the observation group,the incisal edge residual positive rate and occurrence rate of postoperative complications in the control group were significantly higher than those in the observation group( P < 0. 05);the intraoperative bleeding volume and postoperative urine catheter indwelling time had no statistically significant differences between the two groups( P ? 0. 05);after chemotherapy,two groups all had the cases from the grade Ⅰconverting to the grade Ⅱin pathohistology,but this index in the observation group was significantly improved ( P < 0. 05);in addition,the long term follow up displayed that the 3-year and 5-year survival rates in the observation group were significantly higher than those in the control group( P < 0. 05);the adverse reactions in the observation group were obviously milder than those in the control group( P < 0. 05). Conclusion The uterine artery interventional chemotherapy has an exact effect in the treatment of cervical cancer and its long term survival rate and prognosis are superior to the traditional chemotherapeutical method.