CAJ | 학술논문

目的：阻塞性睡眠呼吸暂停（OSA）可能导致患者心功能衰竭。本研究的目的是确定左心室心肌做功指数（IMP），反映无并发症的OSA患者的左心室整体功能。方法：对58例无高血压、糖尿病、及任何心脏或肺部疾病的OSA患者进行整夜多导睡眠图和多普勒超声心动图评价。按照呼吸暂停低通气指数（AHI），受试者被分为三组：第1组，对照组与打鼾者（AHI<5，N=16）；第2组，轻度至中度OSA （AHI：5-30，N=23）；第3组，重度OSAS （AHI>30，N=19）。应用超声心动图测量基本数据，计算IMP指标。左室IMP=（等容收缩时间+等容舒张时间）/主动脉射血时间。结果：三组受试者在年龄、性别、身体质量指数，心率，收缩压和舒张压无显著差异。左室IMP在重度OSA患者比对照组（P<0.01）显著增高。对照组和轻中度OSA、轻中度OSA和重度OSA受试者之间无显著差异。结论：本研究表明，重度OSA可导致左心室整体功能不全。
목적：조새성수면호흡잠정（OSA）가능도치환자심공능쇠갈。본연구적목적시학정좌심실심기주공지수（IMP），반영무병발증적OSA환자적좌심실정체공능。방법：대58례무고혈압、당뇨병、급임하심장혹폐부질병적OSA환자진행정야다도수면도화다보륵초성심동도평개。안조호흡잠정저통기지수（AHI），수시자피분위삼조：제1조，대조조여타한자（AHI<5，N=16）；제2조，경도지중도OSA （AHI：5-30，N=23）；제3조，중도OSAS （AHI>30，N=19）。응용초성심동도측량기본수거，계산IMP지표。좌실IMP=（등용수축시간+등용서장시간）/주동맥사혈시간。결과：삼조수시자재년령、성별、신체질량지수，심솔，수축압화서장압무현저차이。좌실IMP재중도OSA환자비대조조（P<0.01）현저증고。대조조화경중도OSA、경중도OSA화중도OSA수시자지간무현저차이。결론：본연구표명，중도OSA가도치좌심실정체공능불전。
Objective:Obstructive sleep apnea (OSA) may predispose patients to and heart failure.The aim of this study was to determine the index of myocardial performance ( IMP) reflecting left ventricular global function in uncomplicated OSA pa-tients.Methods:Fifty-eight subjects without hypertension,diabetes mellitus, and any cardiac or pulmonary disease referred for evaluation of OSA underwent overnight polysomnography and complete echocardiographic assessment.According to the apnea hy-popnea index ( AHI) , subjects were divided into three groups: group 1, control subjects with nonapneic snorers ( AHI<5,n=16) ;group 2, patients with mild to moderate OSA (AHI:5–30,n=23) ;and group 3, severe OSA (AHI>30, n=19) . Basic echocardiographic measurements LVM index were measured. Left ventricular IMP was calculated as ( isovolumic contraction time+isovolumic relaxation time) /aortic ejection time by Doppler echocardiography. Results:There were no significant differ-ences in age, sex, body mass index, heart rate, and systolic and diastolic blood pressure among the three groups. Left ventricular IMP was significantly higher in severe OSA patients than in controls ( P<0.01) . There was no significant difference between controls and mild to moderate OSAHS and between mild to moderate OSA and severe OSA. Conclusion:The present study demonstrates that patients with severe OSA have global left ventricular dysfunction.