CAJ | 학술논문

目的：复制并评价功能性消化不良脾虚证动物模型。方法运用碘乙酰胺复合小平台劳倦因素造模法，制作功能性消化不良脾虚证动物模型，并观察动物一般状态、体重、饮食情况及胃病理改变，运用糖水偏好试验，球囊试验对功能性消化不良脾虚证进行评价。结果碘乙酰胺及复合小平台大鼠，均出现饮食减少，糖水偏好降低，胃敏感性增高。但碘乙酰胺复合小平台组大鼠体重下降明显，并伴有倦怠等精神症状。结论模型符合功能性消化不良脾虚证标准，但碘乙酰胺复合小平台组脾虚证表征更加明显。
목적：복제병평개공능성소화불량비허증동물모형。방법운용전을선알복합소평태노권인소조모법，제작공능성소화불량비허증동물모형，병관찰동물일반상태、체중、음식정황급위병리개변，운용당수편호시험，구낭시험대공능성소화불량비허증진행평개。결과전을선알급복합소평태대서，균출현음식감소，당수편호강저，위민감성증고。단전을선알복합소평태조대서체중하강명현，병반유권태등정신증상。결론모형부합공능성소화불량비허증표준，단전을선알복합소평태조비허증표정경가명현。
Objective Reconstruction and assessment of animal model of function dyspepsia with spleen deficiency in TCM. Methods Animal model was reconstructed by transient neonatal gastric irrita-tion with iodoacetamide ( IA ) oral gavages and modified multiple platform method. Appearance, body weight, quantity of food and water in-take, sucrose preference, and gastric hypersensitivity were observed to assess whether it is the model of functional dyspepsia with spleen deficiency. Results The IA and IA with modified multiple platform method models all had less food and water in-take, low sucrose preference, and gastric hypersensitivity. The rats of IA with modified multiple platform method got lower body weight and more fatigue. Conclusion Both models met the standards of functional dyspepsia with spleen deficiency, however, IA with modified multiple platform method model appeared more spleen deficiency-like behavioral.