CAJ | 학술논문

痰瘀互结证是冠心病的主要证候类型。在冠心病发生、发展的全过程中都伴随着炎症反应。既往研究表明，以下13个炎症相关指标与冠心病痰瘀互结证存在一定相关性。分别是：C反应蛋白、同型半胱氨酸、细胞因子( TNF-α、IL-6、IL-18、MMPS、MCP-1、M-CSF)、免疫细胞膜分子(CD4\CD4L、PS\PSL、ICAM-1)和脂蛋白(ApoA-Ⅰ、α1-AT)。其中已被公认为冠心病独立危险因素的C反应蛋白、同型半胱氨酸研究证据最多。另外，冠心病患者血中大部分炎症因子水平随着非痰瘀证→痰证/瘀证→痰瘀互结证依次升高，提示痰瘀互结证患者较其他证候炎症程度增高。这些指标有助于痰瘀互结证的客观评估。
담어호결증시관심병적주요증후류형。재관심병발생、발전적전과정중도반수착염증반응。기왕연구표명，이하13개염증상관지표여관심병담어호결증존재일정상관성。분별시：C반응단백、동형반광안산、세포인자( TNF-α、IL-6、IL-18、MMPS、MCP-1、M-CSF)、면역세포막분자(CD4\CD4L、PS\PSL、ICAM-1)화지단백(ApoA-Ⅰ、α1-AT)。기중이피공인위관심병독립위험인소적C반응단백、동형반광안산연구증거최다。령외，관심병환자혈중대부분염증인자수평수착비담어증→담증/어증→담어호결증의차승고，제시담어호결증환자교기타증후염증정도증고。저사지표유조우담어호결증적객관평고。
Intermingled phlegm-blood stasis syndrome is one of the main syndromes in coronary heart disease ( CHD) with inflammation accompanying CHD throughout the whole process. Previous studies indicated that CHD with intermingled phlegm-blood stasis syndrome correlated to 13 inflammatory factors. These 13 factors are C-reactive protein ( CRP) , homocysteinaemia ( HCY) , tumor necrosis factor-α( TNF-α) , interleukin-6 ( IL-6 ) , interleukin-18 ( IL-18 ) , matrix metalloproteinases ( MMPs ) , monocyte che-moattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), macrophage colony stimu-lating factor (M-CSF), CD40/CD40L, PS/PSGL1, ApoA-Ⅰ, andα1-AT. Among them, CRP and HCY, which have widely been considered the independent risk factors of CHD, were more related to CHD with in-termingled phlegm-blood stasis syndrome compared with other inflammatory factors. Besides, the serum levels of inflammatory factors in patients with intermingled phlegm-blood stasis syndrome were higher than those with phlegm syndrome or blood stasis syndrome alone, while patients with non-intermingled phlegm-blood stasis syndrome revealed the lowest serum levels of inflammatory factors. This result showed that pa-tients with intermingled phlegm-blood stasis syndrome had higher level of inflammation than other types of syndrome. The findings may be of help for objective indicators of intermingled phlegm-blood stasis syn-drome.