中华实验和临床感染病杂志(电子版)
中華實驗和臨床感染病雜誌(電子版)
중화실험화림상감염병잡지(전자판)
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2015年
3期
393-396
,共4页
赵燕青%顾梅蕾%张媛媛%翟艳立%邸凤林%刘畅%胡燕%刘永明%苏何玲%钟彦伟
趙燕青%顧梅蕾%張媛媛%翟豔立%邸鳳林%劉暢%鬍燕%劉永明%囌何玲%鐘彥偉
조연청%고매뢰%장원원%적염립%저봉림%류창%호연%류영명%소하령%종언위
肝炎病毒,乙型%胎盘%感染
肝炎病毒,乙型%胎盤%感染
간염병독,을형%태반%감염
Hepatitis B virus%Placental%Infection
目的:研究HBsAg阳性孕妇乙型肝炎病毒血清标志物(HBVM)、HBV DNA含量与胎盘乙型肝炎病毒(HBV)感染的关系,进一步研究胎盘组织在HBV宫内感染中的作用。方法以30例HBsAg阳性足月妊娠孕妇产前外周血及胎盘组织为研究对象。采用酶联免疫吸附试验检测孕妇外周血HBV血清标志物;实时荧光定量PCR方法检测孕妇外周血HBV DNA含量。免疫组织化学染色方法检测胎盘组织HBsAg和HBcAg表达情况。结果30例HBsAg阳性孕妇中,HBeAg阳性18例,HBeAg阴性12例。HBV DNA>104 IU/ml者17例,HBV DNA 102~104 IU/ml者13例。21例胎盘组织HBsAg和HBcAg免疫组织化学染色阳性,胎盘HBV感染率为75%(21/30),HBsAg和HBcAg阳性率分别为55.67%(17/30)和70%(21/30)。HBeAg阳性组中胎盘组织HBV感染率为88.89%(16/18),高于HBeAg阴性组41.67%(5/12),差异有统计学意义(P <0.05);血清中HBV DNA高含量组(>104 IU/ml)胎盘组织HBV感染率为94.12%(16/17),高于低含量组(102~104 IU/ml)患者的胎盘感染率38.46%(5/13),差异有统计学意义(P<0.05)。结论孕妇血清HBeAg阳性和高病毒载量是发生胎盘组织HBV感染的高危因素。胎盘组织是HBV宫内感染传播途径之一。
目的:研究HBsAg暘性孕婦乙型肝炎病毒血清標誌物(HBVM)、HBV DNA含量與胎盤乙型肝炎病毒(HBV)感染的關繫,進一步研究胎盤組織在HBV宮內感染中的作用。方法以30例HBsAg暘性足月妊娠孕婦產前外週血及胎盤組織為研究對象。採用酶聯免疫吸附試驗檢測孕婦外週血HBV血清標誌物;實時熒光定量PCR方法檢測孕婦外週血HBV DNA含量。免疫組織化學染色方法檢測胎盤組織HBsAg和HBcAg錶達情況。結果30例HBsAg暘性孕婦中,HBeAg暘性18例,HBeAg陰性12例。HBV DNA>104 IU/ml者17例,HBV DNA 102~104 IU/ml者13例。21例胎盤組織HBsAg和HBcAg免疫組織化學染色暘性,胎盤HBV感染率為75%(21/30),HBsAg和HBcAg暘性率分彆為55.67%(17/30)和70%(21/30)。HBeAg暘性組中胎盤組織HBV感染率為88.89%(16/18),高于HBeAg陰性組41.67%(5/12),差異有統計學意義(P <0.05);血清中HBV DNA高含量組(>104 IU/ml)胎盤組織HBV感染率為94.12%(16/17),高于低含量組(102~104 IU/ml)患者的胎盤感染率38.46%(5/13),差異有統計學意義(P<0.05)。結論孕婦血清HBeAg暘性和高病毒載量是髮生胎盤組織HBV感染的高危因素。胎盤組織是HBV宮內感染傳播途徑之一。
목적:연구HBsAg양성잉부을형간염병독혈청표지물(HBVM)、HBV DNA함량여태반을형간염병독(HBV)감염적관계,진일보연구태반조직재HBV궁내감염중적작용。방법이30례HBsAg양성족월임신잉부산전외주혈급태반조직위연구대상。채용매련면역흡부시험검측잉부외주혈HBV혈청표지물;실시형광정량PCR방법검측잉부외주혈HBV DNA함량。면역조직화학염색방법검측태반조직HBsAg화HBcAg표체정황。결과30례HBsAg양성잉부중,HBeAg양성18례,HBeAg음성12례。HBV DNA>104 IU/ml자17례,HBV DNA 102~104 IU/ml자13례。21례태반조직HBsAg화HBcAg면역조직화학염색양성,태반HBV감염솔위75%(21/30),HBsAg화HBcAg양성솔분별위55.67%(17/30)화70%(21/30)。HBeAg양성조중태반조직HBV감염솔위88.89%(16/18),고우HBeAg음성조41.67%(5/12),차이유통계학의의(P <0.05);혈청중HBV DNA고함량조(>104 IU/ml)태반조직HBV감염솔위94.12%(16/17),고우저함량조(102~104 IU/ml)환자적태반감염솔38.46%(5/13),차이유통계학의의(P<0.05)。결론잉부혈청HBeAg양성화고병독재량시발생태반조직HBV감염적고위인소。태반조직시HBV궁내감염전파도경지일。
Objective To study the relationship between placental HBV infection and the serum HBVM, HBV DNA levels in pregnant women with HBsAg positive, and to demonstrate the role of placenta in intrauterine infection of hepatitis B virus (HBV). Methods Total of 30 placental tissues and vein blood of HBsAg positive pregnant women were collected. HBVM and HBV DNA were detected by ELISA and RT-PCR, respectively. The expression of HBsAg and HBcAg in placental specimens were detected by immunohistochemistry. Results There were 18 cases with HBeAg positive and 12 cases with HBeAg negative. There were 17 cases with high viral levels group (>104 IU/ml) and 13 cases with low viral levels group (102-104 IU/ml). HBsAg as well as HBcAg were detected in 21 cases among 30 placentas of HBsAg positive pregnant women, the incidences of placental HBV infection were 70%(21/30). The HBV infection rates of placental tissues in the serum of the pregnant women with HBeAg positive were 88.89%(16/18), significant higher than 41.67% (5/12) of HBeAg negative group (P < 0.05). The HBV infection rates of placental tissues were 94.12%(16/17) in 17 pregnant women with HBV DNA>104 IU/ml signiifcantly higher than 38.46%(5/13) in the serum of the pregnant women with low viral levels group (P<0.05). Conclusions Serum HBeAg positive and high viral levels are risk factors of placental HBV infection. Placenta tissues play an important role in intrauterine infection of hepatitis B virus.