CAJ | 학술논문

目的：动态监测多重耐药鲍曼不动杆菌分布及耐药性变迁，指导临床合理用药。方法收集2011年1月至2013年12月本院住院患者各类送检标本，采用DL-96细菌测定系统进行细菌鉴定及药敏试验。结果共分离出多重耐药鲍曼不动杆菌220株，检出率逐年上升，主要分布在ICU （35.9%）、老年病内科（16.8%）和呼吸内科（13.2%）；60岁以上患者检出占76.8%；在痰液中共检出170株，占77.3%。多重耐药鲍曼不动杆菌除米诺环素的耐药率21.8%较低外，其他抗菌药物的耐药率均在60.0%以上，特别是头孢菌素的耐药率已达90.0%以上。对于多重耐药鲍曼不动杆菌的治疗临床应根据药敏结果采用两药联合或三药联合。结论制定合理有效的感染控制措施，合理使用广谱抗菌药物，避免及减少多重耐药鲍曼不动杆菌菌株医院感染的暴发流行。
목적：동태감측다중내약포만불동간균분포급내약성변천，지도림상합리용약。방법수집2011년1월지2013년12월본원주원환자각류송검표본，채용DL-96세균측정계통진행세균감정급약민시험。결과공분리출다중내약포만불동간균220주，검출솔축년상승，주요분포재ICU （35.9%）、노년병내과（16.8%）화호흡내과（13.2%）；60세이상환자검출점76.8%；재담액중공검출170주，점77.3%。다중내약포만불동간균제미낙배소적내약솔21.8%교저외，기타항균약물적내약솔균재60.0%이상，특별시두포균소적내약솔이체90.0%이상。대우다중내약포만불동간균적치료림상응근거약민결과채용량약연합혹삼약연합。결론제정합리유효적감염공제조시，합리사용엄보항균약물，피면급감소다중내약포만불동간균균주의원감염적폭발류행。
Objective To investigate the distribution and the changes in drug resistance of multidrug-resistant Acinetobacter baumannii dynamically, and to guide the rational use of antibiotics. Methods Pathogens isolated from the specimens of inpatients in our hospital since January 2011 to December 2013 were cultured, pathogens identiifcation and drug susceptibility test were performed by DL-96 microorganism analyze system. Results Total of 220 strains of multidrug-resistant Acinetobacter baumannii were isolated, and the detection rate increased year by year. The 220 strains of Acinetobacter baumannii mainly distributed in ICU department (35.9%), geriatrics department (16.8%) and respiratory department (13.2%). There were 76.8% of Acinetobacter baumannii isolated from inpatients over 60 years old and 77.3%isolated from phlegm specimens (170 strains). The resistance rate of multidrug-resistant Acinetobacter baumannii to minocycline was low as 21.8%, but it were more than 60%to other antibiotics. In particular to cephalosporin, the resistance rate of Acinetobacter baumannii reached to above 90.0%. The two or three-drug combination should be taked based on susceptibility of drug for the treatment of multidrug-resistant Acinetobacter baumannii. Conclusions The reasonable and effective measures should be taked to control infection, and use broad-spectrum antibiotics rationally to prevent and reduce nosocomial infection outbreak caused by multidrug-resistant Acinetobacter baumannii.