CAJ | 학술논문

目的：探讨超声引导下射频消融术（ radiofrequency ablation, RFA)联合靶向治疗对晚期肝癌患者生命质量的影响。方法将90例诊断为晚期肝癌的患者随机分为对照组与观察组,每组45例。两组均予吉非替尼联合卡培他滨靶向治疗,观察组在靶向治疗的基础上行超声引导经皮腹腔穿刺RFA,治疗前及治疗后4周采用肿瘤生命质量核心量表（core quality of life questionnaire,QLQ-c30)进行评估并比较。结果治疗后两组QLQ-c30整体功能、特异性症状模块各条目评分均明显优于治疗前,观察组上述指标均优于对照组,差异有统计学意义（ P<0．05)。结论超声引导下RFA联合靶向治疗较单纯靶向治疗能更好地改善晚期肝癌患者的生命质量。
목적：탐토초성인도하사빈소융술（ radiofrequency ablation, RFA)연합파향치료대만기간암환자생명질량적영향。방법장90례진단위만기간암적환자수궤분위대조조여관찰조,매조45례。량조균여길비체니연합잡배타빈파향치료,관찰조재파향치료적기출상행초성인도경피복강천자RFA,치료전급치료후4주채용종류생명질량핵심량표（core quality of life questionnaire,QLQ-c30)진행평고병비교。결과치료후량조QLQ-c30정체공능、특이성증상모괴각조목평분균명현우우치료전,관찰조상술지표균우우대조조,차이유통계학의의（ P<0．05)。결론초성인도하RFA연합파향치료교단순파향치료능경호지개선만기간암환자적생명질량。
Objective To study the effect of radiofrequency ablation combined with targeted therapy on quality of life of patients with advanced hepatocellular carcinoma guided by ultrasound. Methods 90 patients with advanced hepatocellular carcinoma were randomly divided into observation group ( n=45 ) and control group ( n=45 ) . They were treated with Ge-fitinib combined with Capecitabine, and the observation group was treated with additional radiofrequency ablation periappen-diceal abscess guided by ultrasound. Core quality of life questionnaire (QLQ-c30) were assessed and compared 4 weeks be-fore and after treatment. Results After treatment, the Allmerica function, scores of symptom specific modules of QLQ-c30 scores were better than those before treatment in the 2 groups(P<0. 05);and after treatment all the above scores in the obser-vation group were better than those in the control group(P<0. 05). Conclusion Radiofrequency ablation combined with tar-geted therapy can improve quality of life for patients with advanced hepatocellular carcinoma.