中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2015年
3期
347-351
,共5页
结核分枝杆菌%耐药%流行病学分析
結覈分枝桿菌%耐藥%流行病學分析
결핵분지간균%내약%류행병학분석
Mycobacterium tuberculosis%Drug-resistant%Epidemiology analysis
目的：了解徐州地区耐药结核的流行情况及其耐药谱，探讨耐药结核发生的影响因素。方法选择本院收治的涂阳肺结核患者作为研究对象，釆用统一设计的调查表获取患者的基本信息和相关流行病学资料；对研究对象的痰标本进行一线和二线抗结核药物敏感性试验，获取耐药性资料；数据录入Excel表格，采用SPSS 18.0软件进行统计分析。结果本地区总的耐药率为17.29%，耐多药[至少同时耐异烟肼（INH）和利福平（RFP）]率为5.60%，广泛耐药率为0.26%；复治患者的耐药率（37.26%）高于初治患者（13.56%），两者差异有统计学意义（χ2=140.35，P＜0.05）；单一耐药的菌株中耐INH的耐药率最高，在多耐药（对至少两种一线抗结核药耐药，但不包括同时耐INH和RFP）组合中，以INH+SM（链霉素）的组合构成比最高；耐多药组合中，以INH+RFP的组合构成比最高；耐药结核病在不同性别患者中分布的差异无统计学意义，在不同年龄患者中分布具有统计学意义，以41～60岁年龄组耐药率最高。结论徐州地区结核病总耐药率虽然不高，但耐多药率较高，性别分布差异无统计学意义，年龄分布以41～60岁年龄段最多。
目的：瞭解徐州地區耐藥結覈的流行情況及其耐藥譜，探討耐藥結覈髮生的影響因素。方法選擇本院收治的塗暘肺結覈患者作為研究對象，釆用統一設計的調查錶穫取患者的基本信息和相關流行病學資料；對研究對象的痰標本進行一線和二線抗結覈藥物敏感性試驗，穫取耐藥性資料；數據錄入Excel錶格，採用SPSS 18.0軟件進行統計分析。結果本地區總的耐藥率為17.29%，耐多藥[至少同時耐異煙肼（INH）和利福平（RFP）]率為5.60%，廣汎耐藥率為0.26%；複治患者的耐藥率（37.26%）高于初治患者（13.56%），兩者差異有統計學意義（χ2=140.35，P＜0.05）；單一耐藥的菌株中耐INH的耐藥率最高，在多耐藥（對至少兩種一線抗結覈藥耐藥，但不包括同時耐INH和RFP）組閤中，以INH+SM（鏈黴素）的組閤構成比最高；耐多藥組閤中，以INH+RFP的組閤構成比最高；耐藥結覈病在不同性彆患者中分佈的差異無統計學意義，在不同年齡患者中分佈具有統計學意義，以41～60歲年齡組耐藥率最高。結論徐州地區結覈病總耐藥率雖然不高，但耐多藥率較高，性彆分佈差異無統計學意義，年齡分佈以41～60歲年齡段最多。
목적：료해서주지구내약결핵적류행정황급기내약보，탐토내약결핵발생적영향인소。방법선택본원수치적도양폐결핵환자작위연구대상，변용통일설계적조사표획취환자적기본신식화상관류행병학자료；대연구대상적담표본진행일선화이선항결핵약물민감성시험，획취내약성자료；수거록입Excel표격，채용SPSS 18.0연건진행통계분석。결과본지구총적내약솔위17.29%，내다약[지소동시내이연정（INH）화리복평（RFP）]솔위5.60%，엄범내약솔위0.26%；복치환자적내약솔（37.26%）고우초치환자（13.56%），량자차이유통계학의의（χ2=140.35，P＜0.05）；단일내약적균주중내INH적내약솔최고，재다내약（대지소량충일선항결핵약내약，단불포괄동시내INH화RFP）조합중，이INH+SM（련매소）적조합구성비최고；내다약조합중，이INH+RFP적조합구성비최고；내약결핵병재불동성별환자중분포적차이무통계학의의，재불동년령환자중분포구유통계학의의，이41～60세년령조내약솔최고。결론서주지구결핵병총내약솔수연불고，단내다약솔교고，성별분포차이무통계학의의，년령분포이41～60세년령단최다。
Objective To investigate the epidemic characteristics, spectrum and related factors of drug-resistant tuberculosis (TB) in Xuzhou area. Methods Sputum smear-positive patients with TB were selected from Xuzhou Infectious Hospital, the basic information and related epidemiological data of the patients were collected from questionnaire. The ifrst-line and second-line anti-TB drugs sensitivity test was performed. Results The overall rate of resistance to anti-TB drugs was 17.29%. MDR rate was 5.60%and XDR rate was 0.26%. The resistance rates in retreated patients were higher than in initial patients. The single-resistant rate to INH took the highest proportion among all the drugs, the form INH+SM accounted for the largest proportion in multi-resistance, the form INH+RFP accounted for the largest proportion in XDR. The distribution of drug-resistant TB showed no statistically signiifcant difference in different gender, but there was statistically signiifcant difference in different age groups:drug resistance rate was signiifcant higher in 41-60 years group than in other age groups. Conclusions The overall drug-resistance rate in Xuzhou was low, but MDR situation was serious. The distribution of drug-resistant TB showed no statistical signiifcance difference in different gender, drug resistance rate was higher in 41-60 years group than in other age groups.
