CAJ | 학술논문

目的：探讨不同糖代谢状态的慢性乙型肝炎（CHB）患者肝脏炎症及纤维化的差异。方法分析110例CHB患者糖耐量正常、糖耐量异常及糖尿病三种糖代谢状态组肝脏炎症及纤维化的差异。结果碱性磷酸酶、谷氨酰转肽酶及存在脂肪肝的比例均随着糖代谢状态恶化而显著增加，组间比较差异具有统计学意义（P均＜0.05）。肝脏弹性值亦随着糖代谢状态恶化而显著增加，组间比较有统计学意义（F=4.663，P=0.033）。总胆红素亦随着糖代谢状态恶化而有所增加，但组间比较差异无统计学意义（F=3.384，P=0.069）。丙氨酸氨基转移酶和天门冬氨酸氨基转移酶在不同糖代谢状态组间比较差异无统计学意义（F=0.464、0.465，P=0.497、0.497）。糖耐量异常组与糖尿病组肝脏炎症及纤维化各指标比较差异无统计学意义（P均＞0.05）。结论慢性乙型肝炎患者糖代谢异常对肝脏炎症和纤维化均有影响。
목적：탐토불동당대사상태적만성을형간염（CHB）환자간장염증급섬유화적차이。방법분석110례CHB환자당내량정상、당내량이상급당뇨병삼충당대사상태조간장염증급섬유화적차이。결과감성린산매、곡안선전태매급존재지방간적비례균수착당대사상태악화이현저증가，조간비교차이구유통계학의의（P균＜0.05）。간장탄성치역수착당대사상태악화이현저증가，조간비교유통계학의의（F=4.663，P=0.033）。총담홍소역수착당대사상태악화이유소증가，단조간비교차이무통계학의의（F=3.384，P=0.069）。병안산안기전이매화천문동안산안기전이매재불동당대사상태조간비교차이무통계학의의（F=0.464、0.465，P=0.497、0.497）。당내량이상조여당뇨병조간장염증급섬유화각지표비교차이무통계학의의（P균＞0.05）。결론만성을형간염환자당대사이상대간장염증화섬유화균유영향。
Objective To analyze the variance of liver inflammation and fibrosis in different glucose metabolism condition patients with chronic hepatitis B (CHB). Methods The variance of liver inflammation and fibrosis in normal glucose tolerance, impaired glucose tolerance and diabetes mellitus groups in chronic hepatitis B (CHB) were analyzed by the prospective cross-section research. Results The alkaline phosphatase, glutamyl transpeptidase and fatty liver proportion were to worsen signiifcantly along with the glucose metabolism condition degenerating, with signiifcant differences (P all<0.05). Liver stiffness measurement was also worsen significantly along with the glucose metabolism condition degenerating, with signiifcant differences (F=4.663, P=0.033). Total bilirubin tended to increase along with the glucose metabolism condition degenerating, but with no significant difference (F = 3.384, P = 0.069). Alanine aminotransferase and glutamic-oxaloacetic aminotransferase were not signiifcantly different between three glucose metabolism condition groups (F=0.464, 0.465;P=0.497, 0.497). There wasn’t statistic signiifcant difference of liver inlfammation and ifbrosis between impaired glucose tolerance group and diabetes mellitus group (P all>0.05). Conclusions Abnormal glucose metabolism in patients with chronic hepatitis B could inlfuence both liver inlfammation and ifbrosis.