CAJ | 학술논문

呼吸道合胞病毒（RSV）是导致婴幼儿严重下呼吸道感染的最重要病原体，但该病毒的灭活疫苗可引起RSV疫苗增强性疾病（RVED）。RVED的机制目前仍不清楚。Toll样受体（TLR）及其信号转导对 RSV的识别和宿主免疫的激发均有重要作用，其在RVED机制中的作用也日益受到关注。本文主要介绍TLR在抗RSV天然免疫和获得性免疫中的角色及其信号通路激活状态改变对RVED免疫格局的影响，提示RVED机制可能与TLR信号通路激活不足有关，从而为RSV疫苗研制提供新的策略和方法。
호흡도합포병독（RSV）시도치영유인엄중하호흡도감염적최중요병원체，단해병독적멸활역묘가인기RSV역묘증강성질병（RVED）。RVED적궤제목전잉불청초。Toll양수체（TLR）급기신호전도대 RSV적식별화숙주면역적격발균유중요작용，기재RVED궤제중적작용야일익수도관주。본문주요개소TLR재항RSV천연면역화획득성면역중적각색급기신호통로격활상태개변대RVED면역격국적영향，제시RVED궤제가능여TLR신호통로격활불족유관，종이위RSV역묘연제제공신적책략화방법。
Respiratory syncytial virus (RSV) is the most important pathogen responsible for children ’s severe lower respiratory tract infection worldwide . However , no vaccine has been licensed to prevent RSV infection as the inactivated RSV vaccine could enhance disease severity . The exact mechanism of RSV vaccine‐enhanced disease (RVED) remains unclear .Since Toll‐like receptors (TLRs) and their signal pathways play crucial roles in both innate and adaptive immunity ,TLR‐associated RVED mechanism has been proposed and is attracting more and more attentions of researchers .In this review ,we summarized the main progress on the roles of TLRs in anti‐RSV immunity and their signal pathways in affecting the immune status of mice with RVED ,which may enlighten the vaccine design and development .