CAJ | 학술논문

目的：观察瑞舒伐他汀对类风湿关节炎（RA）伴血脂异常患者的疗效。方法选取2013年3月至2014年3月我院风湿科就诊的RA伴血脂异常患者80例，随机分为A、B组，每组40例。A组联合应用甲氨蝶呤、白芍总苷、硫酸羟氯喹治疗，B组在A组治疗基础上加用瑞舒伐他汀。分别于治疗前、治疗后28周记录患者胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、关节肿胀数、关节压痛数、血沉（ESR）、C-反应蛋白（CRP）、DAS28的变化，比较2组不良反应情况。结果治疗28周后，2组患者TC、TG、LDL-C均显著低于治疗前，HDL-C显著高于治疗前（P＜0.05或P＜0.01）；2组患者DAS28、ESR、CRP、关节压痛数、关节肿胀数与治疗前比较均显著降低（均P＜0.01）。B组治疗后DAS28、ESR、CRP改善显著优于A组（P＜0.05或P＜0.01）。2组不良反应发生率无显著差异（P＞0.05）。结论RA患者存在血脂水平异常，瑞舒伐他汀对RA有直接治疗作用。
목적：관찰서서벌타정대류풍습관절염（RA）반혈지이상환자적료효。방법선취2013년3월지2014년3월아원풍습과취진적RA반혈지이상환자80례，수궤분위A、B조，매조40례。A조연합응용갑안접령、백작총감、류산간록규치료，B조재A조치료기출상가용서서벌타정。분별우치료전、치료후28주기록환자담고순（TC）、저밀도지단백담고순（LDL-C）、삼선감유（TG）、고밀도지단백담고순（HDL-C）、관절종창수、관절압통수、혈침（ESR）、C-반응단백（CRP）、DAS28적변화，비교2조불량반응정황。결과치료28주후，2조환자TC、TG、LDL-C균현저저우치료전，HDL-C현저고우치료전（P＜0.05혹P＜0.01）；2조환자DAS28、ESR、CRP、관절압통수、관절종창수여치료전비교균현저강저（균P＜0.01）。B조치료후DAS28、ESR、CRP개선현저우우A조（P＜0.05혹P＜0.01）。2조불량반응발생솔무현저차이（P＞0.05）。결론RA환자존재혈지수평이상，서서벌타정대RA유직접치료작용。
Objective To observe the effection of Rui shu laval statin on lipid proifle in patients with rheumatoid arthritis and its safety.Methods?From?March?2013?to?March?2014?in?the?hospital?department?of?rheumatism,?80?RA?patients?were?randomly?divided?into?A?and?B?two?groups?of?40?cases.?The?a?group?conbined?with?methotrexate,?radix?paeoniae?alba?total?glycosides,?hydroxychloroquine?for?the?treatment?of?RA,?B?group,?based?on?A?group’s?treatment,?were?added?on?Ruishu?laval?statin.?Some?index?were?observed?in?tow?group?before?treatment?and?28?weeks?after?treatment,?were?added?on?Ruishu?laval?statin.?Some?index?were?observed?in?two?group?before?treatment?and?28?weeks?after?treatment,?cholesterol(TC),?low?density?lipoprotein?cholesterol(LDL-C),?triglyceride(TG),?high?density?lipoprotein?cholesterol(HDL-C),?swelling?index,?joint?pain?index,?time?of?morning?stiffness,?C-ractive?protein(CRP),?erythrocyte?sedimentation?rate(ESR),?DAS28.?While?the?patient?in?the?tow?group?therapy?during?the?occurrence?of?adverse?reactions?were?statistically?analyzed.?Results?After?28?weeks?treatment,?TC,?TG,?LDL-C,?both?in?two?groups?of?patients,?were?lower?than?that?before?treatment,?and?HDL-C?higher?than?that before tteament, there were signiifcant differences(P<0.05?or?P<0.01),?after?28?weeks,?DAS28,?ESR,?CRP,?joint?tenderness,?joint?swelling?and?morning?stiffness time, both in two groups RA patients. Compared with before treatment signiifcantly reduced, there were a very signiifcant difference(P<0.05?or?P<0.01).?But?the?therapeutic?effects?of?group?B?were?better?than?those?of?group?A(P<0.05?or?P<0.01).?The?two?group?of?patients?had?adverse?reactions,?mainly?gastrointestinal discomfort and skin itching. Adverse events rates of the e two groups had no signiifcant difference(P>0.05).?Conclusion?RA?patients?have?abnormal?blood?lipid?level,?Ruishu?laval?statin?has?a?direct?effect?on?the?treatment?of?rheumatoid?arthritis.