中华眼科杂志
中華眼科雜誌
중화안과잡지
Chinese Journal of Ophthalmology
2015年
6期
455-457
,共3页
左冰%刘泉%Sally McFadden%Dennis Y.Tse%Rachel K.Chun%杜嗣河
左冰%劉泉%Sally McFadden%Dennis Y.Tse%Rachel K.Chun%杜嗣河
좌빙%류천%Sally McFadden%Dennis Y.Tse%Rachel K.Chun%두사하
近视%功能恢复%屈光,眼%轴长度,眼%脉络膜%豚鼠
近視%功能恢複%屈光,眼%軸長度,眼%脈絡膜%豚鼠
근시%공능회복%굴광,안%축장도,안%맥락막%돈서
Myopia%Recovery of Function%Refraction,ocular%Axial length,eye%Choroid%Guinea pigs
目的 探讨豚鼠离焦性近视去透镜后近视恢复的原因.方法 实验研究.健康豚鼠5只,4日龄时右眼作为实验眼戴-5.00D透镜,左眼作为对照眼.18日龄时去除透镜进行屈光度数、眼轴长度及脉络膜厚度测量,20日龄再次测量.判断近视眼造模是否成功时,采用配对样本t检验对双眼数据进行比较;去透镜后采用独立样本t检验对双眼数据进行比较.结果 18日龄时,实验眼相对对照眼产生(-2.00±1.50)D的相对近视(P=0.04),并且产生了(0.033±0.025) mm的相对眼轴长度延长(P=0.04).20日龄时,双眼相对近视已经恢复至(-0.72±0.86)D(P=0.13),但相对性眼轴长度延长仍然存在(0.031±0.022) mm(P=0.04).在相对近视恢复的早期过程中,正常对照眼的屈光与眼轴长度呈一致性变化,而近视恢复眼实验眼的屈光与眼轴长度呈反向分离性变化.结论 豚鼠经透镜诱导的相对性轴性近视在去除透镜后恢复可能与脉络膜的增厚以及眼球生长速度下降有关.
目的 探討豚鼠離焦性近視去透鏡後近視恢複的原因.方法 實驗研究.健康豚鼠5隻,4日齡時右眼作為實驗眼戴-5.00D透鏡,左眼作為對照眼.18日齡時去除透鏡進行屈光度數、眼軸長度及脈絡膜厚度測量,20日齡再次測量.判斷近視眼造模是否成功時,採用配對樣本t檢驗對雙眼數據進行比較;去透鏡後採用獨立樣本t檢驗對雙眼數據進行比較.結果 18日齡時,實驗眼相對對照眼產生(-2.00±1.50)D的相對近視(P=0.04),併且產生瞭(0.033±0.025) mm的相對眼軸長度延長(P=0.04).20日齡時,雙眼相對近視已經恢複至(-0.72±0.86)D(P=0.13),但相對性眼軸長度延長仍然存在(0.031±0.022) mm(P=0.04).在相對近視恢複的早期過程中,正常對照眼的屈光與眼軸長度呈一緻性變化,而近視恢複眼實驗眼的屈光與眼軸長度呈反嚮分離性變化.結論 豚鼠經透鏡誘導的相對性軸性近視在去除透鏡後恢複可能與脈絡膜的增厚以及眼毬生長速度下降有關.
목적 탐토돈서리초성근시거투경후근시회복적원인.방법 실험연구.건강돈서5지,4일령시우안작위실험안대-5.00D투경,좌안작위대조안.18일령시거제투경진행굴광도수、안축장도급맥락막후도측량,20일령재차측량.판단근시안조모시부성공시,채용배대양본t검험대쌍안수거진행비교;거투경후채용독립양본t검험대쌍안수거진행비교.결과 18일령시,실험안상대대조안산생(-2.00±1.50)D적상대근시(P=0.04),병차산생료(0.033±0.025) mm적상대안축장도연장(P=0.04).20일령시,쌍안상대근시이경회복지(-0.72±0.86)D(P=0.13),단상대성안축장도연장잉연존재(0.031±0.022) mm(P=0.04).재상대근시회복적조기과정중,정상대조안적굴광여안축장도정일치성변화,이근시회복안실험안적굴광여안축장도정반향분리성변화.결론 돈서경투경유도적상대성축성근시재거제투경후회복가능여맥락막적증후이급안구생장속도하강유관.
Objective To investigate changes in refractive status and ocular length in guinea pigs during the early time of myopic recovery for the causes of recovery.Methods Exp guinea pigs wore a-5.00 D lens on one eye from 4-18 days,which was then removed for 48 hours.At 18 and 20 days of age,each eye was evaluated for refractive status and ocular length of the eye.Results The right eyes treated with-5 D lenses for 12 days developed (-2.00± 1.50) D (P=0.04) of myopia and had an increase in axial length of (0.033±0.025) mm compared to the left eyes (P=0.04).After 48 hours of recovery,the difference between the two eyes was reduced to (-0.72±0.86) D(P=0.13),but the ocular length still had significant difference (0.031±0.022) mm (P=0.04).During the myopia recovery early period,the refractive status and ocular length changed in the same direction in the left eyes but in the opposite way in the right eyes.Conclusions Guinea pigs treated with-5.00 D lenses for 12 days developed explicit relative axial myopia.After removal of the lens for 48 hours,myopia significantly recovery can be due to the thickening of choroid and the reduction in ocular growth.
