CAJ | 학술논문

目的：研究A型肉毒毒素（ BTX-A）治疗偏头痛的机理。方法建立偏头痛大鼠模型，分别应用BTX-A皮下注射（ BTX-A组）及生理盐水注射（生理盐水组）治疗，并设立健康对照（对照组）。采用放射免疫法测定各组降钙素基因相关肽（CGRP）和P物质（SP）含量。结果生理盐水组CGRP、SP含量高于对照组（P均＜0．05）， BTX-A组低于生理盐水组（ P均＜0．05）。结论 BTX-A抑制三叉神经感觉通路CGRP及SP释放可能是其治疗偏头痛大鼠的机制之一。
목적：연구A형육독독소（ BTX-A）치료편두통적궤리。방법건립편두통대서모형，분별응용BTX-A피하주사（ BTX-A조）급생리염수주사（생리염수조）치료，병설립건강대조（대조조）。채용방사면역법측정각조강개소기인상관태（CGRP）화P물질（SP）함량。결과생리염수조CGRP、SP함량고우대조조（P균＜0．05）， BTX-A조저우생리염수조（ P균＜0．05）。결론 BTX-A억제삼차신경감각통로CGRP급SP석방가능시기치료편두통대서적궤제지일。
Objective To explore the mechanism of botulinum toxin type A ( BTX-A) in treatment of migraine of rats.Methods The migraine rat models were established and then were respectively given subcutaneous injection of BTX -A (BTX-A group) and normal saline (NS group); additionally, the healthy rats were selected as the control group .The contents of calcitonin gene related peptide ( CGRP) and substance P ( SP) were detected by radioimmunoassay .Results The contents of CGRP and SP in the NS group were higher than those of the control group , but they decreased significantly in the BTX-A group as compared with those of the NS group (all P<0.05).Conclusion BTX-A inhibits SP and CGRP releasing from trigeminal sensory pathways , which may be one of the mechanisms of BTX-A in treatment of migraine .