中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2015年
15期
68-70
,共3页
早发型子痫前期%硫酸镁%低分子肝素
早髮型子癇前期%硫痠鎂%低分子肝素
조발형자간전기%류산미%저분자간소
Early-onset preeclampsia%Magnesium%Low molecular weight heparin
目的：探讨低分子肝素联合硫酸镁治疗早发型子痫前期的效果。方法选取2012年1月~2014年1月本院收治的早发型子痫前期患者56例，将其随机分为观察组和对照组，各28例。对照组采用硫酸镁进行治疗，观察组在对照组治疗的基础上给予低分子肝素进行治疗。比较两组治疗前后的血小板(PLT)计数、凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及D-二聚体的变化，记录两组孕产妇的产后出血情况。结果治疗前，两组的PLT计数、PT、TT、APTT、FIB及D-二聚体比较，差异无统计学意义(P跃0.05)；治疗后，两组的PLT计数差异无统计学意义(P跃0.05)，观察组的PT、TT、APTT较对照组延长，FIB及D-二聚体较对照组减少，差异有统计学意义(P<0.05)。观察组的产后出血量为(327.4±78.2)ml，对照组为(274.6±86.7)ml，两组的产后出血量差异无统计学意义(P跃0.05)。结论低分子肝素联合硫酸镁治疗早发型子痫前期患者可明显改善患者的高凝状态，且不会增加出血风险。
目的：探討低分子肝素聯閤硫痠鎂治療早髮型子癇前期的效果。方法選取2012年1月~2014年1月本院收治的早髮型子癇前期患者56例，將其隨機分為觀察組和對照組，各28例。對照組採用硫痠鎂進行治療，觀察組在對照組治療的基礎上給予低分子肝素進行治療。比較兩組治療前後的血小闆(PLT)計數、凝血酶原時間(PT)、凝血酶時間(TT)、部分凝血活酶時間(APTT)、纖維蛋白原(FIB)及D-二聚體的變化，記錄兩組孕產婦的產後齣血情況。結果治療前，兩組的PLT計數、PT、TT、APTT、FIB及D-二聚體比較，差異無統計學意義(P躍0.05)；治療後，兩組的PLT計數差異無統計學意義(P躍0.05)，觀察組的PT、TT、APTT較對照組延長，FIB及D-二聚體較對照組減少，差異有統計學意義(P<0.05)。觀察組的產後齣血量為(327.4±78.2)ml，對照組為(274.6±86.7)ml，兩組的產後齣血量差異無統計學意義(P躍0.05)。結論低分子肝素聯閤硫痠鎂治療早髮型子癇前期患者可明顯改善患者的高凝狀態，且不會增加齣血風險。
목적：탐토저분자간소연합류산미치료조발형자간전기적효과。방법선취2012년1월~2014년1월본원수치적조발형자간전기환자56례，장기수궤분위관찰조화대조조，각28례。대조조채용류산미진행치료，관찰조재대조조치료적기출상급여저분자간소진행치료。비교량조치료전후적혈소판(PLT)계수、응혈매원시간(PT)、응혈매시간(TT)、부분응혈활매시간(APTT)、섬유단백원(FIB)급D-이취체적변화，기록량조잉산부적산후출혈정황。결과치료전，량조적PLT계수、PT、TT、APTT、FIB급D-이취체비교，차이무통계학의의(P약0.05)；치료후，량조적PLT계수차이무통계학의의(P약0.05)，관찰조적PT、TT、APTT교대조조연장，FIB급D-이취체교대조조감소，차이유통계학의의(P<0.05)。관찰조적산후출혈량위(327.4±78.2)ml，대조조위(274.6±86.7)ml，량조적산후출혈량차이무통계학의의(P약0.05)。결론저분자간소연합류산미치료조발형자간전기환자가명현개선환자적고응상태，차불회증가출혈풍험。
Objective To investigate the effect of low molecular weight heparin combined with magnesium in treatment of early-onset preeclampsia. Methods 56 patients with early-onset preeclampsia treated in our hospital from January 2012 to January 2014 were selected,and they were randomly divided into observation group and control group,there were 28 cases in each group.Control group was treated with magnesium,while observation group was treated with low molecular weight heparin on the basis of control group.Platelet (PLT) count,prothrombin time (PT),thrombin time (TT), activated partial thromboplastin time (APTT),fibrinogen (FIB) and D-dimer of two groups before and after treatment was compared,postpartum hemorrhage was recorded. Results Before treatment,PLT count,PT,TT,APTT,FIB and D-dimer of two groups had no significant difference (P>0.05);after treatment,PLT count between two groups had no significant dif-ference (P>0.05),PT,TT,APTT of observation group was longer than that of control group respectively,FIB and D-dimer was decreased compared with that of control group,the difference was significant (P<0.05). Postpartum hemorrhage of the observation group was (327.4±78.2) ml,the postpartum hemorrhage of the control group was (274.6±86.7) ml,two groups had no significant difference (P>0.05). Conclusion Low molecular weight heparin and magnesium in treatment of patients with early-onset preeclampsia can significantly improve the hypercoagulable state in patients,and does not increase the risk of bleeding.
