CAJ | 학술논문

世界卫生组织的调查报告显示糖尿病是导致人类死亡的三大主要原因之一。糖尿病患者基数大、传统药物治疗专一性不足，因此高效、专一、副作用小的糖尿病药物成为药物研究的热点问题。人成纤维细胞生长因子-21(FGF-21)是由FGF基因家族成员编码的细胞生长因子，具有广泛的生物学活性。研究表明其可以独立于胰岛素摄取葡萄糖，并与胰岛素有协同作用；可以显著降低血糖及血脂水平，改善胰岛素抵抗和胰岛β细胞功能。随着研究的深入，FGF-21将有望成为与胰岛素替代、竞争或联合用药的2型糖尿病治疗的一线药物。本文对FGF-21的结构、功能和现阶段研究进展分别进行了阐述。
세계위생조직적조사보고현시당뇨병시도치인류사망적삼대주요원인지일。당뇨병환자기수대、전통약물치료전일성불족，인차고효、전일、부작용소적당뇨병약물성위약물연구적열점문제。인성섬유세포생장인자-21(FGF-21)시유FGF기인가족성원편마적세포생장인자，구유엄범적생물학활성。연구표명기가이독립우이도소섭취포도당，병여이도소유협동작용；가이현저강저혈당급혈지수평，개선이도소저항화이도β세포공능。수착연구적심입，FGF-21장유망성위여이도소체대、경쟁혹연합용약적2형당뇨병치료적일선약물。본문대FGF-21적결구、공능화현계단연구진전분별진행료천술。
The World Health Organization’s survey shows that diabetes is one of the three major causes of human deaths.Because of the large number of patients with diabetes,the traditional medicine treatment is less specific,the dia-betes drugs with high efficiency,specificity and side effects is the hot issues of drug research.Fibroblast growth factor-21(FGF-21) is a cell growth factor encoded by the members of the FGF gene family, and has a wide range of biological activity.The study shows that it can be independent of the insulin,and have a synergistic effect with insulin.It can sig-nificantly reduce blood glucose and blood lipid levels,improve insulin resistance and islet β-cell function.With the in-depth study,FGF-21 is expected to become a first-line drug with insulin replacement,competition or combination of type 2 diabetes treatment.This paper describes the structure,function and current research progress of FGF-21.