CAJ | 학술논문

目的：观察口服普萘洛尔治疗婴幼儿眼部血管瘤的有效性及安全性。方法24位年龄1~10个月的眼部血管瘤患儿，排除使用普萘洛尔禁忌症后，按普萘洛尔2mg/kg/日剂量进行口服治疗，监测心率血压至少72小时后保持出院继续治疗并保持随访。每月复查肿块B超、血糖、心率及血压，观察评估血管瘤变化及处理不良反应，根据肿块大小及B超情况择期减量至1mg/kg/日维持量，治疗疗程为6~18个月，并对治疗效果进行评价。结果24位病人通过治疗后，23人外观肿块消失者，1人仍可见眼睑肿胀、可扪及肿块。效果评价为Ⅳ级者23人（23/24，95.83%），Ⅱ级者1人（1/24，4.17%）。所有病人服药期间未见明显心率及血压降低。随访中3位年龄小于3个月的患儿出现睡眠不安、肝功能异常及低血糖反应。结论对于婴幼儿眼部血管瘤，口服普萘洛尔是一种安全有效的治疗方法。
목적：관찰구복보내락이치료영유인안부혈관류적유효성급안전성。방법24위년령1~10개월적안부혈관류환인，배제사용보내락이금기증후，안보내락이2mg/kg/일제량진행구복치료，감측심솔혈압지소72소시후보지출원계속치료병보지수방。매월복사종괴B초、혈당、심솔급혈압，관찰평고혈관류변화급처리불량반응，근거종괴대소급B초정황택기감량지1mg/kg/일유지량，치료료정위6~18개월，병대치료효과진행평개。결과24위병인통과치료후，23인외관종괴소실자，1인잉가견안검종창、가문급종괴。효과평개위Ⅳ급자23인（23/24，95.83%），Ⅱ급자1인（1/24，4.17%）。소유병인복약기간미견명현심솔급혈압강저。수방중3위년령소우3개월적환인출현수면불안、간공능이상급저혈당반응。결론대우영유인안부혈관류，구복보내락이시일충안전유효적치료방법。
Objective To observe the efficacy and safety of oral propranolol for treatment of infantile ocular he-mangioma. Methods 24 patients aged 1 to 10 months with ocular hemangioma underwent oral propranolol treatment after excluding the contraindications. The mean dose was 2mg/kg/day and treatment went on at home after monitoring the heart rate and blood pressure for 72 hours in hospital. The patients were followed-up monthly and evaluated with ultrasound ex-amination,blood glucose,heart rate,blood pressure and adverse effect. According to the tumor size and ultrasound, the dose reduced to 1mg/kg/day and the treatment continued for 6 to 18 months. Results 23 patients had no tumor in appearence,but 1 patient still had visible tumor. The treatment responses were considered scale Ⅳ(excellent)in 23 patients(23/24,95.83%) and scale II(moderate) in 1 patient (1/24,4.17%). No patients had bradycardia and hypotension and only 3 patients had sleep disturbance, liver dysfunction and hypoglycemia. Conclusions Oral pro-pranolol is a safe and effective treatment for infantile ocular hemangioma.