CAJ | 학술논문

影响结直肠癌（ Colorectal cancer ，CRC）患者预后的因素除了一些临床病理学因素外，各类宿主免疫反应也成为影响预后的关键因素。因而，结直肠癌治疗方式除了传统的治疗模式之外，抗肿瘤免疫治疗逐渐成为当前治疗热点。调节性T细胞（ Regulatory T，Treg）通过免疫调节机制参与免疫反应过程，并发挥重要的作用。叉头转录因子3（ Forkhead box P3，Foxp3）作为调节性T细胞表达的调控因子之一，对Treg细胞通过抑制多种免疫细胞的增殖分化来发挥重要的作用。 Foxp3＋Treg细胞在结直肠癌患者中的表达与预后关系密切。该综述旨在阐明Foxp3与Treg细胞的基本特征、Foxp3＋Treg细胞发挥肿瘤抑制性作用的机制、Foxp3在Treg细胞中表达对结直肠癌患者预后的重要意义进行阐述。
영향결직장암（ Colorectal cancer ，CRC）환자예후적인소제료일사림상병이학인소외，각류숙주면역반응야성위영향예후적관건인소。인이，결직장암치료방식제료전통적치료모식지외，항종류면역치료축점성위당전치료열점。조절성T세포（ Regulatory T，Treg）통과면역조절궤제삼여면역반응과정，병발휘중요적작용。차두전록인자3（ Forkhead box P3，Foxp3）작위조절성T세포표체적조공인자지일，대Treg세포통과억제다충면역세포적증식분화래발휘중요적작용。 Foxp3＋Treg세포재결직장암환자중적표체여예후관계밀절。해종술지재천명Foxp3여Treg세포적기본특정、Foxp3＋Treg세포발휘종류억제성작용적궤제、Foxp3재Treg세포중표체대결직장암환자예후적중요의의진행천술。
In addition to the traditional treatment mode of colorectal cancer (Colorectal cancer,CRC), anti tumor immune treatment gradually becomes the focus .In addition to some clinical pathological factors which affect the prognosis of colorectal carcinoma ,the host′s immune response becomes a hotspot .Treg cells involves in immune reaction through immunomodulatory mechanism .Foxp3 as a regulator of Treg plays an important role though suppress proliferation and differentiation of immune cell .The relationship between the expression of Foxp 3 in Treg and prognosis in patients with colorectal cancer is closely .The review is to clarify the basic characters of Foxp3 and Treg,the mechanism of Foxp3+Treg cell,the significance between the expression of Foxp 3 in Treg and the prognosis of colorectal cancer .