CAJ | 학술논문

长链非编码RNAs（Long non－coding RNAS，lncRNAs）是一类不编码蛋白质，长度大于200个核苷酸的RNA。结直肠癌的发生发展与lncRNA的异常表达密切相关。本文结合近年来国内外的文献报道，对lncRNA在结直肠癌中的表达情况及作用机制做一综述，以期为临床诊断和靶向治疗提供可能的依据。
장련비편마RNAs（Long non－coding RNAS，lncRNAs）시일류불편마단백질，장도대우200개핵감산적RNA。결직장암적발생발전여lncRNA적이상표체밀절상관。본문결합근년래국내외적문헌보도，대lncRNA재결직장암중적표체정황급작용궤제주일종술，이기위림상진단화파향치료제공가능적의거。
Long non-coding RNA ( lncRNA ) is a group of RNAs that exceed 200 nt in length without protein coding capacity .The tumorigenesis and progression of colorectal carcinoma relate to the aberrant expres-sion of lncRNAs closely.In this review,we summarize researches in the current status of lncRNAs in human color-ectal carcinoma to provide potential evidences for future diagnosis and gene therapies .