包头医学院学报
包頭醫學院學報
포두의학원학보
JOURNAL OF BAOTOU MEDICAL COLLEGE
2015年
6期
31-32,33
,共3页
慢性心衰%NT-proBNP%心功能分级
慢性心衰%NT-proBNP%心功能分級
만성심쇠%NT-proBNP%심공능분급
Chronic heart failure%NT-proBNP%Heart function grading
目的：探讨不同分级的慢性心力衰竭（chronic heart failure，CHF）患者血浆中，B 型脑钠肽前体 N端片段（N－terminal proB－NP，NT－proBNP）水平的差异及其相关性。方法：选取2012年1月至2014年8月收治的120例慢性心衰患者与120例非慢性心衰患者作为研究对象，其中慢性心衰患者作为观察组，心功能分级依据纽约心脏病协会（ new york heart association，NYHA）提出的心功能分级标准对慢性心衰患者进行分级，非慢性心衰患者作为对照组，采用电化学发光免疫法检测血浆中NT－proBNP水平，比较两组患者血浆中NT－proBNP的水平以及不同分级慢性心衰患者血浆中NT－proBNP水平。结果：（1）观察组患者血浆中 NT －proBNP的水平为（9018．03±274．91）pg／mL，对照组患者血浆中NT－proBNP的水平为（261．63±72．18）pg／mL，观察组患者血浆中NT－proBNP的水平明显高于对照组，其差异具有统计学意义（ t ＝25．1461， P ＜0．05）；（2）NYHA 分级Ⅳ级患者血浆中 NT－proBNP 的水平明显低于 NYHA 分级Ⅰ级、Ⅱ级、Ⅲ级患者，比较差异有统计学意义（ P ＜0．05）；NYHA分级Ⅲ级患者血浆中NT－proBNP的水平明显低于NYHA分级Ⅰ级、Ⅱ级患者，比较差异有统计学意义（ P ＜0．05）；NYHA分级Ⅱ级患者血浆中NT－proBNP的水平明显低于 NYHA分级Ⅰ级患者，比较差异有统计学意义（ P ＜0．05）。结论：慢性心衰患者的血浆NT－proBNP水平随着心功能的逐渐下降而出现升高现象，血浆中 NT－proB－NP的检测可以作为判断心功能不全的较为敏感的临床指标，可能成为临床上的常规检测指标。
目的：探討不同分級的慢性心力衰竭（chronic heart failure，CHF）患者血漿中，B 型腦鈉肽前體 N耑片段（N－terminal proB－NP，NT－proBNP）水平的差異及其相關性。方法：選取2012年1月至2014年8月收治的120例慢性心衰患者與120例非慢性心衰患者作為研究對象，其中慢性心衰患者作為觀察組，心功能分級依據紐約心髒病協會（ new york heart association，NYHA）提齣的心功能分級標準對慢性心衰患者進行分級，非慢性心衰患者作為對照組，採用電化學髮光免疫法檢測血漿中NT－proBNP水平，比較兩組患者血漿中NT－proBNP的水平以及不同分級慢性心衰患者血漿中NT－proBNP水平。結果：（1）觀察組患者血漿中 NT －proBNP的水平為（9018．03±274．91）pg／mL，對照組患者血漿中NT－proBNP的水平為（261．63±72．18）pg／mL，觀察組患者血漿中NT－proBNP的水平明顯高于對照組，其差異具有統計學意義（ t ＝25．1461， P ＜0．05）；（2）NYHA 分級Ⅳ級患者血漿中 NT－proBNP 的水平明顯低于 NYHA 分級Ⅰ級、Ⅱ級、Ⅲ級患者，比較差異有統計學意義（ P ＜0．05）；NYHA分級Ⅲ級患者血漿中NT－proBNP的水平明顯低于NYHA分級Ⅰ級、Ⅱ級患者，比較差異有統計學意義（ P ＜0．05）；NYHA分級Ⅱ級患者血漿中NT－proBNP的水平明顯低于 NYHA分級Ⅰ級患者，比較差異有統計學意義（ P ＜0．05）。結論：慢性心衰患者的血漿NT－proBNP水平隨著心功能的逐漸下降而齣現升高現象，血漿中 NT－proB－NP的檢測可以作為判斷心功能不全的較為敏感的臨床指標，可能成為臨床上的常規檢測指標。
목적：탐토불동분급적만성심력쇠갈（chronic heart failure，CHF）환자혈장중，B 형뇌납태전체 N단편단（N－terminal proB－NP，NT－proBNP）수평적차이급기상관성。방법：선취2012년1월지2014년8월수치적120례만성심쇠환자여120례비만성심쇠환자작위연구대상，기중만성심쇠환자작위관찰조，심공능분급의거뉴약심장병협회（ new york heart association，NYHA）제출적심공능분급표준대만성심쇠환자진행분급，비만성심쇠환자작위대조조，채용전화학발광면역법검측혈장중NT－proBNP수평，비교량조환자혈장중NT－proBNP적수평이급불동분급만성심쇠환자혈장중NT－proBNP수평。결과：（1）관찰조환자혈장중 NT －proBNP적수평위（9018．03±274．91）pg／mL，대조조환자혈장중NT－proBNP적수평위（261．63±72．18）pg／mL，관찰조환자혈장중NT－proBNP적수평명현고우대조조，기차이구유통계학의의（ t ＝25．1461， P ＜0．05）；（2）NYHA 분급Ⅳ급환자혈장중 NT－proBNP 적수평명현저우 NYHA 분급Ⅰ급、Ⅱ급、Ⅲ급환자，비교차이유통계학의의（ P ＜0．05）；NYHA분급Ⅲ급환자혈장중NT－proBNP적수평명현저우NYHA분급Ⅰ급、Ⅱ급환자，비교차이유통계학의의（ P ＜0．05）；NYHA분급Ⅱ급환자혈장중NT－proBNP적수평명현저우 NYHA분급Ⅰ급환자，비교차이유통계학의의（ P ＜0．05）。결론：만성심쇠환자적혈장NT－proBNP수평수착심공능적축점하강이출현승고현상，혈장중 NT－proB－NP적검측가이작위판단심공능불전적교위민감적림상지표，가능성위림상상적상규검측지표。
Objective:To investigate the difference of NT -proBNP level in plasma and its correlation in patients with chronic heart failure ( CHF) of different grade.Methods:120 cases of chronic heart failure and 120 cases of non-chronic heart failure were selected as the research ob-jects in the observation group and in the control group respectively, and the heart function grading of the former group was conducted based on the heart function grading standard established by New YorkHeart Association(NYHA).NT-proBNP levels in plasma were detected with electrochem-iluminescence immunoassay, with NT-proBNP levels in plasma compared in the two groups and among patients with CHF in different grades.Re-sults: (1) NT-proBNP level in plasma in the observation group (9018.03 ±274.91 pg/mL) was significantly higher than that in the control group (261.63 ±72.18 pg/mL) ( t =25.1461, P <0.05);(2) NT-proBNP level in plasma of patients in grade IV of NYHA grading was sig-nificantly lower than that in gradeⅠ、Ⅱ、and Ⅲ of the same grading( P <0.05); NT-proBNP level in plasma of patients in grade Ⅲ of NYHA grading was significantly lower than that of grade Ⅰand Ⅱ of NYHA grading ( P <0 .05 ); plasma NT -proBNP level in patients with NYHA grade II was significantly lower than that in patients with NYHA grade Ⅰ( P <0.05).Conclusion:NT-proBNP level in plasma of patients with CHF presents with increase with the gradual decreasing of cardiac function .The detection of NT-proBNP in plasma can be used as a relatively sensitive clinical index for the determination of cardiac dysfunction , which may become a routine detection index in clinical medicine .
