CAJ | 학술논문

目的：检测胰岛素样生长因子1受体（IGF－1R）和胰岛素受体底物1（IRS－1）在肺鳞癌组织中的表达，探究其在肺鳞癌发生发展中的作用及临床意义。方法采用免疫组化法检测246例肺鳞癌组织与40例癌旁正常组织中IGF－1R、IRS－1的表达情况，并分析两者的相关性及与临床病理特征和预后的关系。结果 IGF －1R 在肺鳞癌组织中的阳性表达率明显高于癌旁组织，其表达率分别为54．07％和32．5％，IRS－1在肺鳞癌组织中的阳性表达率明显低于癌旁组织，其表达率分别为38．21％和70％，各组间差异均有统计学意义（P＜0．05）。 IGF－1R的表达与淋巴结转移相关（P＜0．05），IRS－1的表达与肺鳞癌组织的分化程度、淋巴结转移相关（P＜0．05）。 IGF－1R阳性表达组患者的生存期明显短于IGF－1R阴性表达组患者，IRS－1阳性表达组患者的生存期明显长于IRS－1阴性表达组患者，差异有统计学意义（P＜0．001，P＜0．05）。 IGF－1R与IRS－1在肺鳞癌组织中的表达呈负相关（r＝－0．125，P＜0．001）。结论 IGF－1R、IRS－1都参与了肺鳞癌的发生、发展，且IGF－1R为独立预后因子。
목적：검측이도소양생장인자1수체（IGF－1R）화이도소수체저물1（IRS－1）재폐린암조직중적표체，탐구기재폐린암발생발전중적작용급림상의의。방법채용면역조화법검측246례폐린암조직여40례암방정상조직중IGF－1R、IRS－1적표체정황，병분석량자적상관성급여림상병리특정화예후적관계。결과 IGF －1R 재폐린암조직중적양성표체솔명현고우암방조직，기표체솔분별위54．07％화32．5％，IRS－1재폐린암조직중적양성표체솔명현저우암방조직，기표체솔분별위38．21％화70％，각조간차이균유통계학의의（P＜0．05）。 IGF－1R적표체여림파결전이상관（P＜0．05），IRS－1적표체여폐린암조직적분화정도、림파결전이상관（P＜0．05）。 IGF－1R양성표체조환자적생존기명현단우IGF－1R음성표체조환자，IRS－1양성표체조환자적생존기명현장우IRS－1음성표체조환자，차이유통계학의의（P＜0．001，P＜0．05）。 IGF－1R여IRS－1재폐린암조직중적표체정부상관（r＝－0．125，P＜0．001）。결론 IGF－1R、IRS－1도삼여료폐린암적발생、발전，차IGF－1R위독립예후인자。
Objective The aim of the study is to detect the expression of IGF -1R and IRS-1 in squa-mous cell lung cancer ( SQCLC) and to explore the role in the development of squamous cell lung cancer and clini -cal significance .Methods Specimens from 246 surgical SQCLC and 40 adjacent normal lung tissues were evalu-ated for IGF-1R and IRS-1 expression by immunohistochemistry .We explored the correlation between IGF -1R and IRS-1,their relationship with clinicopathological parameters and their impact on outcome in SQCLC pa -tients.Results SQCLC of IGF -1R positive expression rate was 54.07%,which was higher than in adjacent normal tissue(32.5%),SQCLC of IRS-1 positive expression rate was 38.21%,which was lower than in adja-cent normal tissue(70%),the pairwise difference was statistically significant (P<0.05);Expression of IGF-1R was correlated with lymph node metastasis (P<0.05),IRS-1 expression was related with degree of differentia-tion and lymph node metastasis (P<0.05).Survival of IGF -1R expression group of patients was significantly shorter than the expression of IGF -1R negative patients ,the survival of the IRS-1 expression was significantly longer than patients who negatively expressed IRS -1,the difference was statistically significant (P=<0.001 and=0.021).IGF-1R was negatively correlated with IRS -1 expression in SQCLC(r=-0.125,P<0.001). Conclusion IGF-1R,IRS-1 are involved in the occurrence of SQCLC ,the development .The IGF-1R is an independent prognostic factor in SQCLC .