CAJ | 학술논문

目的：探讨青少年分化型甲状腺癌的临床特点及131 I治疗的临床疗效。方法回顾性分析2011年1月—2013年1月收治的181例分化型甲状腺癌患者的临床资料及随访结果，其中包括青少年患者（21岁及以下）36例，非青少年患者（21岁以上）145例，所有患者均进行131 I治疗，并进行随访。结果青少年组的淋巴结转移和远处转移发生率均高于非青少年组（P＜0．05）。青少年组患者131I治疗的有效率为91．7％，非青少年组患者有效率为82．1％。青少年组患者随访期内未发现131I 治疗引起肺纤维化、生长发育异常和继发肿瘤等不良事件发生。结论青少年分化型甲状腺癌更易发生局部淋巴结转移或远处转移，131 I治疗青少年分化型甲状腺癌是一种安全有效的方法。
목적：탐토청소년분화형갑상선암적림상특점급131 I치료적림상료효。방법회고성분석2011년1월—2013년1월수치적181례분화형갑상선암환자적림상자료급수방결과，기중포괄청소년환자（21세급이하）36례，비청소년환자（21세이상）145례，소유환자균진행131 I치료，병진행수방。결과청소년조적림파결전이화원처전이발생솔균고우비청소년조（P＜0．05）。청소년조환자131I치료적유효솔위91．7％，비청소년조환자유효솔위82．1％。청소년조환자수방기내미발현131I 치료인기폐섬유화、생장발육이상화계발종류등불량사건발생。결론청소년분화형갑상선암경역발생국부림파결전이혹원처전이，131 I치료청소년분화형갑상선암시일충안전유효적방법。
Objective To investigate the clinical characteristics and effect of the 131 I therapy in the ado-lescents with differentiated thyroid carcinoma .Methods The clinical and follow up data of 181 patients with dif-ferentiated thyroid carcinoma who received initial 131 I treatment from January 2011 to January 2013 were retro-spectively analyzed.There were 36 cases of adolescent patients (21 years old or younger),and 145 cases of adult patients(More than 21 years old).Results The incidence of lymph node metastasis and distant metastasis in ad-olescent group were higher than that in the non -adolescent group ( P<00.5 ) .The effective rate of adolescent pa-tients with 131 I treatment was 91.7%,and the effective rate was 82.1%in non-adolescent group .No pulmonary fibrosis,abnormity of growth and secondary malignancies were found during follow -up.Conclusion Adolescent patients with differentiated thyroid cancer are more likely to occur local lymph node metastasis or distant metasta -sis.131 I therapy is an effective and safe method for young patients with differentiated thyroid carcinoma .