CAJ | 학술논문

目的：观察温阳祛风活血法治疗早期糖尿病周围血管病变的临床疗效。方法将120例早期糖尿病周围血管病变患者随机分为治疗组60例、对照组60例。治疗过程中脱落2例。2组均采取控制血糖、血压等基础治疗。治疗组加用口服祛风活血中药汤剂、外用温阳活血中药汤剂。对照组加服己酮可可碱肠溶片。观察2组临床疗效，2组踝肱指数（ ABI）及足背动脉血流量。结果治疗组59例中，显效11例（18．6％），有效37例（62．7％），无效11例（18．6％），总有效率为81.4％；对照组59例中，显效9例（15．3％），有效28例（47．5％），无效22例（37．3％），总有效率为62．7％。经Ridit分析，U＝－2．198，P＝0．039，P＜0．05，说明治疗组临床疗效优于对照组。2组ABI治疗后较本组治疗前均增加（P＜0．05），治疗组前后差值较对照组增加明显（P＜0．01），治疗组优于对照组。足背动脉血流量治疗组治疗后较本组治疗前增加（P＜0．01），对照组治疗前后差异无统计学意义（P＞0．05），治疗组前后差值较对照组增加明显（P＜0．01），治疗组优于对照组。结论温阳祛风活血法内外同治，对早期糖尿病周围血管病变有较好的临床疗效。
목적：관찰온양거풍활혈법치료조기당뇨병주위혈관병변적림상료효。방법장120례조기당뇨병주위혈관병변환자수궤분위치료조60례、대조조60례。치료과정중탈락2례。2조균채취공제혈당、혈압등기출치료。치료조가용구복거풍활혈중약탕제、외용온양활혈중약탕제。대조조가복기동가가감장용편。관찰2조림상료효，2조과굉지수（ ABI）급족배동맥혈류량。결과치료조59례중，현효11례（18．6％），유효37례（62．7％），무효11례（18．6％），총유효솔위81.4％；대조조59례중，현효9례（15．3％），유효28례（47．5％），무효22례（37．3％），총유효솔위62．7％。경Ridit분석，U＝－2．198，P＝0．039，P＜0．05，설명치료조림상료효우우대조조。2조ABI치료후교본조치료전균증가（P＜0．05），치료조전후차치교대조조증가명현（P＜0．01），치료조우우대조조。족배동맥혈류량치료조치료후교본조치료전증가（P＜0．01），대조조치료전후차이무통계학의의（P＞0．05），치료조전후차치교대조조증가명현（P＜0．01），치료조우우대조조。결론온양거풍활혈법내외동치，대조기당뇨병주위혈관병변유교호적림상료효。
Objective To observe the effect of early diabetic peripheral vascular disease with warming yang, expelling pathogenic wind and activating blood circulation.Methods 120 patients with early diabetic peripheral vascular disease were divided into treatment group ( n=60 ) and control group ( n=60 ) , there were 2 expulsion cases in this study.Regular treatments were given to both groups to control the blood glucose and blood pressure.Besides, oral administration of dispelling pathogenic wind for activating blood circulation herbs were taken by treatment group, as well as external use of warming yang for blood circulation herbs.Pentoxifylline was given to the control group.Ankle brachial pressure index ( ABI) and blood flow volume of dorsalispedis artery were recorded.Results In treatment group ( n=59), 11 cases had significant effect (18.6%), 37 cases showed effective (62.7%), 11 cases were presented as ineffective ( 18 .6%) , the total effective rate was 81 .4%; In control group ( n=59 ) , 9 cases had significant effect (15.3%), 28 cases showed effective (47.5%), 22 cases were presented as ineffective (37.3%), the total effective rate was 62.7%; Ridit analyzes showed U=-2.198, P=0.039( P<0.05 ) , which indicated treatment group was superior to control group.ABI of both groups improved significantly than those before treatment(P<0.05), the differentials of treatment group was significantly higher than control group ( P<0 .01 ) , the treatment group was superior to control group. Blood flow volume ofdorsalispedis artery of treatment group increased significantly than that before treatment ( P <0.01 ) , while there was no statistical significance in control group ( P >0.05 ) . Significant differences of clinical effect were showed in the internal and external development group and pentoxifylline treatment group ( P<0 .05 ) .the differentials of treatment group was significantly higher than control group ( P<0.01 ) , the treatment group was superior to control group.Conclusions The internal and external use of warming yang, expelling pathogenic wind and activating blood circulation method shows good curative effect on early diabetic peripheral vascular disease.