CAJ | 학술논문

目的：观察糖脂平对代谢综合征（ MS）患者胰岛素敏感性及超敏C反应蛋白（ hs-CRP）和肿瘤坏死因子α（ TNF-α）的影响。方法采用随机平行对照的方法将符合入选标准的70例MS者分为治疗组35例、对照组35例，治疗组在原治疗的基础上给予中药糖脂平汤药口服，对照组在原治疗的基础上给予罗格列酮口服。观察2组治疗前后胰岛素作用指数（ IAI ）、胰岛素抵抗指数（ HOMA-IR）、hs-CRP和TNF-α的变化情况。结果完成临床试验的65例中，治疗组33例，对照组32例。治疗后2组的IAI水平均升高，与本组治疗前比较，差异均有统计学意义（ P＜0．01）；组间比较差异无统计学意义（ P＞0．05）。治疗后2组的HOMA-IR水平均下降，与本组治疗前比较，差异均有统计学意义（P＜0.01）；组间比较差异无统计学意义（P＞0．05）。治疗前2组的hs-CRP均有轻度升高，治疗后2组的hs-CRP均较本组治疗前明显降低（ P＜0．01）；治疗前后组间比较差异均无统计学意义（ P＞0.05）。治疗后2组的TNF-α水平均明显降低，与本组治疗前比较，差异均有统计学意义（P＜0．01）；治疗后组间比较差异无统计学差异（P＞0．05）。结论糖脂平可有效改善MS患者的胰岛素敏感性，同时可以降低炎症因子hs-CRP和TNF-α的水平。
목적：관찰당지평대대사종합정（ MS）환자이도소민감성급초민C반응단백（ hs-CRP）화종류배사인자α（ TNF-α）적영향。방법채용수궤평행대조적방법장부합입선표준적70례MS자분위치료조35례、대조조35례，치료조재원치료적기출상급여중약당지평탕약구복，대조조재원치료적기출상급여라격렬동구복。관찰2조치료전후이도소작용지수（ IAI ）、이도소저항지수（ HOMA-IR）、hs-CRP화TNF-α적변화정황。결과완성림상시험적65례중，치료조33례，대조조32례。치료후2조적IAI수평균승고，여본조치료전비교，차이균유통계학의의（ P＜0．01）；조간비교차이무통계학의의（ P＞0．05）。치료후2조적HOMA-IR수평균하강，여본조치료전비교，차이균유통계학의의（P＜0.01）；조간비교차이무통계학의의（P＞0．05）。치료전2조적hs-CRP균유경도승고，치료후2조적hs-CRP균교본조치료전명현강저（ P＜0．01）；치료전후조간비교차이균무통계학의의（ P＞0.05）。치료후2조적TNF-α수평균명현강저，여본조치료전비교，차이균유통계학의의（P＜0．01）；치료후조간비교차이무통계학차이（P＞0．05）。결론당지평가유효개선MS환자적이도소민감성，동시가이강저염증인자hs-CRP화TNF-α적수평。
Objective To observe the effect of Tangzhiping on insulin sensitivity, high sensitive C reactive protein ( hs-CRP ) and tumor necrosis factor-α( TNF-α) in patients with metabolic syndrome ( MS) .Methods 70 MS patients who met with defined criteria were randomly divided into treatment group (n=35) and control group (n=35).Besides the original treatment,Tangzhiping and rosiglitazone were given to the treatment group and control group separately for 12 weeks.Insulin action index ( IAI) , insulin resistance index ( IRI ) , hs-CRP and TNF-αwere observed before and after treatment in two groups.Results There were 65 patients fulfilled this trial, among which 33 were treated with Tangzhiping, and 32 were treated with rosiglitazone.IAI were all increased significantly in two groups than those before treatment(P <0.01).There was no statistical significance between two groups(P>0.05).IR were all decreased in both groups than those before treatment ( P<0.01).There was no statistical significance between two groups(P>0.05).The levels of hs-CRP were all higher than the reference value in two groups before treatment.The level of hs-CRP were all decreased in two groups than those before treatment ( P<0 .01 ) , but there was no statistical significance between two groups ( P>0.05).The level of TNF-αwere all decreased in two groups than those before treatment (P<0.01), but there was no statistical significance between two groups( P >0.05).Conclusions Tangzhiping could improve insulin sensitivity of patient with MS.It could also decrease the levels of hs-CRP and TNF-α.