CAJ | 학술논문

目的：：探索雌激素受体-β(ER-β)基因多态性及山茶籽油与广西壮族妇女绝经后骨质疏松症(PMOP)的关联性。方法：590例广西长期食用山茶籽油壮族妇女和600例广西长期非食用山茶籽油壮族妇女,定量超声骨质密度仪检测2组右侧足跟骨测量宽带超声衰减值(BUA),PCR-RFLP 检测2组 ER-β基因多态性。结果：同一年龄组相比较,食用山茶籽油组绝经妇女骨质疏松症的患病率明显低于非食用山茶籽油组绝经妇女。ER-β基因 RsaⅠ等位基因频率在2组中存在着显著性差异,r 等位基因患 PMOP 的风险是 R 等位基因的1.442倍(OR=1.442,95%CI 为1.215~1.711)。食用山茶籽油组绝经后骨质疏松症组携带 AluⅠ酶切位点的 a 等位基因分布频率明显少于非食用山茶籽油组绝经后骨质疏松症组。结论：提示 ER-βRsaⅠ酶切位点的 r 等位基因可能是 PMOP 的遗传易感基因；食用山茶籽油对 PMOP 有防治作用,AluⅠ酶切位点的 a 等位基因是对山茶籽油起交互作用的敏感基因。
목적：：탐색자격소수체-β(ER-β)기인다태성급산다자유여엄서장족부녀절경후골질소송증(PMOP)적관련성。방법：590례엄서장기식용산다자유장족부녀화600례엄서장기비식용산다자유장족부녀,정량초성골질밀도의검측2조우측족근골측량관대초성쇠감치(BUA),PCR-RFLP 검측2조 ER-β기인다태성。결과：동일년령조상비교,식용산다자유조절경부녀골질소송증적환병솔명현저우비식용산다자유조절경부녀。ER-β기인 RsaⅠ등위기인빈솔재2조중존재착현저성차이,r 등위기인환 PMOP 적풍험시 R 등위기인적1.442배(OR=1.442,95%CI 위1.215~1.711)。식용산다자유조절경후골질소송증조휴대 AluⅠ매절위점적 a 등위기인분포빈솔명현소우비식용산다자유조절경후골질소송증조。결론：제시 ER-βRsaⅠ매절위점적 r 등위기인가능시 PMOP 적유전역감기인；식용산다자유대 PMOP 유방치작용,AluⅠ매절위점적 a 등위기인시대산다자유기교호작용적민감기인。
Obj ective :To explore the correlation of polymorphism of estrogen receptor-β(ER-β)and camellia seed oil with post-menopausal osteoporosis (PMOP)in Zhuang women of Guangxi.Methods :5 9 0 and 6 0 0 Zhuang women,who ingested regularly or nerve intook camellia oil (ECO)in long-term (grouped as ECO and NECO correspondingly),underwent right calcaneal broad band ultrasound attenuation (BUA) analysis by using quantitative ultrasound bone densitomerter,ER-βpolymorphism detection using PCR-RFLP.Results :In the same age subgroup,the prevalence of PMOP in ECO group was significantly lower than that in NECO group.The difference in ER-βgene Rsa Ⅰ allele frequencies was found in the above two groups.And,risk for PMOP with allele r was 1 .4 4 2 times than that of R allele (OR= 1 .4 4 2 ,9 5 % CI:1 .2 1 5 1 .7 1 1 ). The frequency of Alu Ⅱ restriction a allele occurred in ECO women with PMOP was significantly less than that in NECO women with PMOP.Conclusion:The ER-β r allele gene may be a genetic susceptibility gene of PMOP;intake of camellia seed oil has preventive and therapeutic effect on PMOP, and a allele may be a sensitive gene in the interaction with camellia oil.