新医学
新醫學
신의학
NEW CHINESE MEDICINE
2015年
6期
414-416
,共3页
李国栋%成志勇%王凤云%谢旭磊%张爱红%谢娜
李國棟%成誌勇%王鳳雲%謝旭磊%張愛紅%謝娜
리국동%성지용%왕봉운%사욱뢰%장애홍%사나
铅中毒%慢性%骨髓增生异常综合征%继发
鉛中毒%慢性%骨髓增生異常綜閤徵%繼髮
연중독%만성%골수증생이상종합정%계발
Lead poisoning,chronic%Myelodysplastic syndromes%Secondary
骨髓增生异常综合征(MDS )是多能造血干细胞的恶性克隆性疾病,以骨髓无效造血,外周血一系或多系血细胞减少,骨髓一系或多系病态造血为特征,并具有向急性白血病转化等风险。MDS 可分为原发性及继发性。研究表明铅中毒可导致造血系统紊乱,该文报道1例因长期接触铅而引发继发性 MDS (s-MDS)的患者,其血铅、尿铅明显升高,全血细胞减少,伴有克隆性染色体异常。经予排铅治疗后,患者血常规恢复至接近正常水平,随访情况稳定。因此,临床上对于铅中毒且出现血常规异常的患者,应进一步行骨髓及染色体检查以排除 s-MDS 的可能。
骨髓增生異常綜閤徵(MDS )是多能造血榦細胞的噁性剋隆性疾病,以骨髓無效造血,外週血一繫或多繫血細胞減少,骨髓一繫或多繫病態造血為特徵,併具有嚮急性白血病轉化等風險。MDS 可分為原髮性及繼髮性。研究錶明鉛中毒可導緻造血繫統紊亂,該文報道1例因長期接觸鉛而引髮繼髮性 MDS (s-MDS)的患者,其血鉛、尿鉛明顯升高,全血細胞減少,伴有剋隆性染色體異常。經予排鉛治療後,患者血常規恢複至接近正常水平,隨訪情況穩定。因此,臨床上對于鉛中毒且齣現血常規異常的患者,應進一步行骨髓及染色體檢查以排除 s-MDS 的可能。
골수증생이상종합정(MDS )시다능조혈간세포적악성극륭성질병,이골수무효조혈,외주혈일계혹다계혈세포감소,골수일계혹다계병태조혈위특정,병구유향급성백혈병전화등풍험。MDS 가분위원발성급계발성。연구표명연중독가도치조혈계통문란,해문보도1례인장기접촉연이인발계발성 MDS (s-MDS)적환자,기혈연、뇨연명현승고,전혈세포감소,반유극륭성염색체이상。경여배연치료후,환자혈상규회복지접근정상수평,수방정황은정。인차,림상상대우연중독차출현혈상규이상적환자,응진일보행골수급염색체검사이배제 s-MDS 적가능。
Myelodysplastic syndrome (MDS)is malignant cloning disease of multipotential stem cells characterized by ineffective hematopoiesis of the bone marrow,peripheral single-or multi-lineage pancytopenia and single-or multi-lineage dyaplasia,and has a risk of evolving into acute leukemia.MDS can be divided into primary and secondary categories.It has been proven that lead poisoning can result in hematopoietic system dis-orders.In this paper,we reported one patient developing secondary MDS (s-MDS)after long-term exposure to lead.The patient presented with significantly elevated levels of lead in the blood and urine,pancytopenia and clonal chromosome abnormalities.After lead excretion,routine blood test revealed almost normal outcomes. The patient was physically stable during subsequent follow-up.Therefore,patients with lead poisoning and ab-normality of routine blood test should further receive bone marrow and chromosome examinations to exclude the possibility of s-MDS.