CAJ | 학술논문

目的：研究甲状腺功能亢进（甲亢）、甲状腺功能减退（甲减）患者及正常人中血清瘦素水平及其与甲状腺激素的关系。方法选取正常体质量的甲亢患者29例（甲亢组）、甲减患者22例（甲减组）、健康体检合格者35名（正常对照组）。采用电化学发光法检测血清 FT3、FT4和TSH；采用放射免疫法检测血清瘦素水平。结果甲亢患者血清瘦素水平（10．01±5．67）ng／ml 高于对照组（5．36±2．11）ng／ml 及甲减组（5．40±1．99）ng／ml （P 均＜0．01）；甲减组瘦素水平与对照组比较差异无统计学意义（P ＞0．05）。Pearson 相关分析显示，瘦素与 FT3、FT4呈正相关（FT3：r ＝0．728，P ＜0．01；FT4：r ＝0．776，P ＜0．01），而与 BMI 和 TSH 无显著相关性（P ＞0．05）。结论血清瘦素水平在甲亢患者中高于正常，与 FT3、FT4呈正相关，提示瘦素的表达与甲状腺功能状态具有一定的相关性。
목적：연구갑상선공능항진（갑항）、갑상선공능감퇴（갑감）환자급정상인중혈청수소수평급기여갑상선격소적관계。방법선취정상체질량적갑항환자29례（갑항조）、갑감환자22례（갑감조）、건강체검합격자35명（정상대조조）。채용전화학발광법검측혈청 FT3、FT4화TSH；채용방사면역법검측혈청수소수평。결과갑항환자혈청수소수평（10．01±5．67）ng／ml 고우대조조（5．36±2．11）ng／ml 급갑감조（5．40±1．99）ng／ml （P 균＜0．01）；갑감조수소수평여대조조비교차이무통계학의의（P ＞0．05）。Pearson 상관분석현시，수소여 FT3、FT4정정상관（FT3：r ＝0．728，P ＜0．01；FT4：r ＝0．776，P ＜0．01），이여 BMI 화 TSH 무현저상관성（P ＞0．05）。결론혈청수소수평재갑항환자중고우정상，여 FT3、FT4정정상관，제시수소적표체여갑상선공능상태구유일정적상관성。
Objective To study the correlation between serum leptin levels and thyroid hormones concentration in patients with hyper-and hypo-thyroidism,and healthy subjects.Methods Twenty nine hy-perthyroid patients with normal weight (hyperthyroidism group),22 hypothyroid cases (hypothyroidism group) and 35 healthy controls (control group)were recruited in this investigation.Serum thyroid-stimulating hormone (TSH),free triiodothyronine (FT3 )and free thyroxine (FT4 )levels were measured with electrochemilumines-cent immunoassay (ECLIA)method.Serum leptin level was assessed by radio-immunoassay (RIA).Results The serum leptin level in hyperthyroid patients was (1 0.01 ±5.67)ng/mL,significantly higher compared with (5.36 ±2.1 1 )ng/mL in healthy controls and(5.40 ±1 .99)ng/mL in hypothyroid patients(both P <0.01 ). The serum leptin levels did not significantly differ between the hypothyroid and control groups (P >0.05). Pearson correlation analysis revealed that serum leptin level was positively correlated with FT4 and FT3 levels (FT3:r =0.728,P <0.01 ;FT4:r =0.776,P <0.01 ),but had no correlation with BMI and TSH.Conclu-sions Serum leptin level in hyperthyroid patients was higher than that in normal controls.Leptin level was positively correlated with FT3 and FT3 levels,suggesting that leptin expression was associated with thyroidal function to certain extent.