CAJ | 학술논문

目的：：研究负极性驻极体作用在糖尿病大鼠皮肤两侧静电场的稳定性及其对糖尿病大鼠皮肤组织结构的影响,探讨负极性驻极体透皮给药的机制。方法：利用电晕充电技术将聚丙烯薄膜制备成不同表面电位的负极性驻极体,以糖尿病大鼠为模型,借助等温表面电位衰减测量和光学显微镜,研究大鼠皮肤两侧电场的稳定性及驻极体对大鼠皮肤显微结构的影响。结果：-1500 V 驻极体作用糖尿病大鼠24 h,透过糖尿病大鼠皮肤的电位是其初始电位的68%,显示糖尿病大鼠皮肤能处于较稳定的外电场中；糖尿病大鼠皮肤的角质层和全皮随-1500 V 驻极体作用时间的延长而逐渐恢复,表皮层和真皮层细胞排列变得逐渐清晰,但排列仍较为松散,皮下脂肪组织萎缩部分恢复。结论：负极性驻极体能为糖尿病大鼠皮肤两侧提供一定大小的静电场；驻极体产生的静电场可改善糖尿病大鼠皮肤的显微结构,使糖尿病皮肤角质层和真皮层细胞排列疏松,有利于药物透过皮肤。
목적：：연구부겁성주겁체작용재당뇨병대서피부량측정전장적은정성급기대당뇨병대서피부조직결구적영향,탐토부겁성주겁체투피급약적궤제。방법：이용전훈충전기술장취병희박막제비성불동표면전위적부겁성주겁체,이당뇨병대서위모형,차조등온표면전위쇠감측량화광학현미경,연구대서피부량측전장적은정성급주겁체대대서피부현미결구적영향。결과：-1500 V 주겁체작용당뇨병대서24 h,투과당뇨병대서피부적전위시기초시전위적68%,현시당뇨병대서피부능처우교은정적외전장중；당뇨병대서피부적각질층화전피수-1500 V 주겁체작용시간적연장이축점회복,표피층화진피층세포배렬변득축점청석,단배렬잉교위송산,피하지방조직위축부분회복。결론：부겁성주겁체능위당뇨병대서피부량측제공일정대소적정전장；주겁체산생적정전장가개선당뇨병대서피부적현미결구,사당뇨병피부각질층화진피층세포배렬소송,유리우약물투과피부。
Obj ective :The purpose of this study was to evaluate the stability of the electrostatic field on both sides of the skin in diabetic rats generated by negative electret.And the effects of skin structure were investigated after different surface potential electrets.This paper for more scientifically,discussed the transdermal delivery mechanism of negative electrets.Methods :Polypropylene (PP)electret was prepared with a corona charging system under different charging conditions.The surface potential of the electrets as measured using a surface potentiometer.Equivalent surface potential decay was measured and the optical microscope was used to evaluate the stability of the electret field on both sides of the skin and the skin microstructure by the effect of electret.Results :(1 )The surface potential of the electret could penetrate through the diabetic rat skin after 2 4 h continuous function and stayed about 6 8 % of the initial surface potential.It means that the skins of diabetic rat could be in a stable electrostatic field.(2 )Stratum corneum and full leather of the diabetic rats skin became thicker and thicker with the- 1 5 0 0 V electret.The epidermis and dermis cells arranged mare clearly than the diabetic control rats,but the arrangement was relatively looser after - 1 5 0 0 V electret’s action.At the same time,the atrophy area of hypodermis restored partially. Conclusion:(1 )Negative electret can provide a certain size electrostatic field for both sides of the skin of diabetic rats. (2 )Electrostatic field generated by electret can improve the microstucture and loosen the stratum corneum and dermis cells of diabetic rats’skin.Electret is expected to be used for transdermal drug preparation.