CAJ | 학술논문

探讨溶栓胶囊防治急性高原病(AHAD)的效果。对急进4300 m高原的112名官兵分别口服溶栓胶囊(A组，n=32，0.25 g/粒，4粒/次)、复方红景天胶囊(B组，n=40，0.38 g/粒，2粒/次)和安慰剂(C组，n=40，炒面胶囊，2粒/次)，每天早晚各服1次。进驻高原前3d开始服药，进驻高原途中(4d)及进驻后(8d)连续服用，共服药15d。进驻高原后第l、3、5、7 d检测SaO2，并依据随访记录受试者每天的AHAD症状，然后分度评分。A组与B组较C组第3、5、7 d的AHAD症状评分和发病率均降低，SaO2增高(<0.05或<0.01)；A组与B组AHAD症状评分无统计学差异(>0.05)，但A组对急性缺氧所致心慌、气短、胸闷、失眠等AHAD症状的发生率较B组和C组明显降低(<0.05或<0.01)。溶栓胶囊能改善AHAD症状，对缺氧所致心慌、气短、胸闷等症状防治效果优于复方红景天。
탐토용전효낭방치급성고원병(AHAD)적효과。대급진4300 m고원적112명관병분별구복용전효낭(A조，n=32，0.25 g/립，4립/차)、복방홍경천효낭(B조，n=40，0.38 g/립，2립/차)화안위제(C조，n=40，초면효낭，2립/차)，매천조만각복1차。진주고원전3d개시복약，진주고원도중(4d)급진주후(8d)련속복용，공복약15d。진주고원후제l、3、5、7 d검측SaO2，병의거수방기록수시자매천적AHAD증상，연후분도평분。A조여B조교C조제3、5、7 d적AHAD증상평분화발병솔균강저，SaO2증고(<0.05혹<0.01)；A조여B조AHAD증상평분무통계학차이(>0.05)，단A조대급성결양소치심황、기단、흉민、실면등AHAD증상적발생솔교B조화C조명현강저(<0.05혹<0.01)。용전효낭능개선AHAD증상，대결양소치심황、기단、흉민등증상방치효과우우복방홍경천。
To explore the effect of Thrombolytic capsules in prevention and treatment of the acute high altitude diseases (AHAD). Total 112 army-men to be urgently deployed at the 4300 m high altitude were divided into three groups and orally took Thrombolytic capsules (group A, n = 32, 0.25 g per capsule, four capsules per time), compound rhodiola capsules (group B, n = 40, 0.38g per capsule, two capsules per time) and placebo (group C, chow mein capsules, n = 40, two capsules per time) in the morning and evening every day. The medication lasted for 15 days including three days before the deployment, four days during the deployment and eight days after the deployment at high altitude. At the 1st, 3rd, 5th and 7th day after the deployment, their SaO2 were examined and then index scores were made according to AHAD symptoms of the subjects in the follow-up notes. Comparing with group C, AHAD symptom scores and disease occurrence rates at the 3rd, 5th and 7th day in group A and B were lower, but the SaO2 was higher ( < 0.05 or < 0.01); AHAD symptom scores in group A and B had no statistic difference ( >0.05), but the AHAD occurrence rate in group A, such as palpitation, hard breathe, chest choking sense and agrypnia, was significantly lower than that in group B and C ( < 0.05 or < 0.01). Thrombolytic capsule can improve AHAD symptoms, and compared with compound rhodiolae, it can also achieve a better effect in prevention of AHAD symptoms, such as palpitation, hard breathe, chest choking sense and agrypnia, resulted from oxygen deficit.