实用检验医师杂志
實用檢驗醫師雜誌
실용검험의사잡지
Chinese Journal of Laboratory Pathologist
2015年
2期
97-99
,共3页
过敏性紫癜%早期肾损伤%尿微量白蛋白%血清胱抑素C%儿童
過敏性紫癜%早期腎損傷%尿微量白蛋白%血清胱抑素C%兒童
과민성자전%조기신손상%뇨미량백단백%혈청광억소C%인동
Henoch-schonlein purpura%Early renal damage%Urinary micro-albumin%Serum cystatin C%Children
目的：探讨血清胱抑素C（cystatin， CysC）和尿微量白蛋白（micro－albumin， mALB）在过敏性紫癜（henoch－schonlein purpura， HSP）患儿早期肾功能损伤中的临床应用价值。方法收集2014年1月至2014年12月我院皮肤科120例HSP患儿病历资料，根据其肾功能划分为肾功能正常组（60例）和肾功能异常组（60例），同时选取60例健康体检儿童为对照组。检测受试儿童血清CysC和尿mALB水平，对检测结果进行统计学分析。结果对照组、肾功能正常HSP组、肾功能异常HSP组血清CysC和尿mALB检测结果差异均有统计学意义（F＝7.13，F＝8.54，P均＜0.05）。肾功能正常HSP组和肾功能异常HSP组血清CysC和尿mALB检测结果均高于对照组，且差异均有统计学意义（P均＜0.05）；肾功能异常HSP组血清CysC和尿mALB检测结果高于肾功能正常HSP组，且差异均有统计学意义（P均＜0.05）。 HSP组血清CysC、尿mALB及二者联合检测阳性率均高于对照组，且差异均有统计学意义（P均＜0.05）；HSP组血清CysC和尿mALB联合检测的阳性率高于两指标单独检测的阳性率，且差异均有统计学意义（P均＜0.05）。结论血清CysC和尿mALB可作为预测HSP患儿早期肾损伤的敏感指标。
目的：探討血清胱抑素C（cystatin， CysC）和尿微量白蛋白（micro－albumin， mALB）在過敏性紫癜（henoch－schonlein purpura， HSP）患兒早期腎功能損傷中的臨床應用價值。方法收集2014年1月至2014年12月我院皮膚科120例HSP患兒病歷資料，根據其腎功能劃分為腎功能正常組（60例）和腎功能異常組（60例），同時選取60例健康體檢兒童為對照組。檢測受試兒童血清CysC和尿mALB水平，對檢測結果進行統計學分析。結果對照組、腎功能正常HSP組、腎功能異常HSP組血清CysC和尿mALB檢測結果差異均有統計學意義（F＝7.13，F＝8.54，P均＜0.05）。腎功能正常HSP組和腎功能異常HSP組血清CysC和尿mALB檢測結果均高于對照組，且差異均有統計學意義（P均＜0.05）；腎功能異常HSP組血清CysC和尿mALB檢測結果高于腎功能正常HSP組，且差異均有統計學意義（P均＜0.05）。 HSP組血清CysC、尿mALB及二者聯閤檢測暘性率均高于對照組，且差異均有統計學意義（P均＜0.05）；HSP組血清CysC和尿mALB聯閤檢測的暘性率高于兩指標單獨檢測的暘性率，且差異均有統計學意義（P均＜0.05）。結論血清CysC和尿mALB可作為預測HSP患兒早期腎損傷的敏感指標。
목적：탐토혈청광억소C（cystatin， CysC）화뇨미량백단백（micro－albumin， mALB）재과민성자전（henoch－schonlein purpura， HSP）환인조기신공능손상중적림상응용개치。방법수집2014년1월지2014년12월아원피부과120례HSP환인병력자료，근거기신공능화분위신공능정상조（60례）화신공능이상조（60례），동시선취60례건강체검인동위대조조。검측수시인동혈청CysC화뇨mALB수평，대검측결과진행통계학분석。결과대조조、신공능정상HSP조、신공능이상HSP조혈청CysC화뇨mALB검측결과차이균유통계학의의（F＝7.13，F＝8.54，P균＜0.05）。신공능정상HSP조화신공능이상HSP조혈청CysC화뇨mALB검측결과균고우대조조，차차이균유통계학의의（P균＜0.05）；신공능이상HSP조혈청CysC화뇨mALB검측결과고우신공능정상HSP조，차차이균유통계학의의（P균＜0.05）。 HSP조혈청CysC、뇨mALB급이자연합검측양성솔균고우대조조，차차이균유통계학의의（P균＜0.05）；HSP조혈청CysC화뇨mALB연합검측적양성솔고우량지표단독검측적양성솔，차차이균유통계학의의（P균＜0.05）。결론혈청CysC화뇨mALB가작위예측HSP환인조기신손상적민감지표。
Objective To explore the clinical value of serum cystatin C(CysC) and urinary micro-al-bumin(mALB) detection in the diagnosis of early renal function damage in the children with henoch-schonlein purpura (HSP). Methods 120 cases of HSP children from January 2014 to December 2014 in our hospital department of dermatology were collected. They were divided into normal renal function group (60 cases) and renal dysfunction group(60 cases) according to their renal function. In the same time, 60 healthy children were chosen as control group. The levels of serum CysC and urine mALB of all the children were detected and the re-sults were analyzed statistically. Results There were statistical significance in the differences of serum CysC and urine mALB levels among control group, normal renal function group and renal dysfunction group (F=7.13, F=8.54, Pall<0.05). The serum CysC and urine mALB levels in normal renal function group and renal dysfunction group were all higher than that of control group , and the differences all had statistical significance (Pall<0.05). The serum CysC and urine mALB levels in renal dysfunction group were all higher than that of normal renal function group, and the differences all had statistical significance(Pall<0.05). The positive rates of serum CysC, urine mALB and combine detection in HSP group were all higher than that of control group, and the differences all had statistical significance (Pall<0.05). The positive rates of serum CysC and urine mALB were all lower than that of combine detection, and the differences all had statistical significance (Pall<0.05). Conclusion The serum CysC and urine mALB can be used as the index for the diagnosis of early renal function in the children with HSP.
