CAJ | 학술논문

探讨联合应用铝碳酸镁能否提高标准三联疗法对幽门螺杆菌(HP)的根除率。216例HP感染患者随机分为研究组(n=108)与对照组(n=108)。对照组给予标准三联疗法(奥美拉唑20 mg，阿莫西林1 g，克拉霉素0.5 g，口服，2次/d，疗程14 d)；研究组在对照组基础上，加用铝碳酸镁片1 g，嚼服，3次/d，疗程14 d。比较两组HP根除率。研究组HP根除率(80.6%)高于对照组(71.3%)，但两组相比无显著差异(χ2=2.5328，>0.05)；研究组中胃溃疡及十二指肠球部溃疡患者HP根除率均达100%，均分别显著高于对照组(70.6%，73.9%)(<0.05)。联合应用铝碳酸镁能增强标准三联疗法对HP、尤其是消化性溃疡患者HP的根除率。
탐토연합응용려탄산미능부제고표준삼련요법대유문라간균(HP)적근제솔。216례HP감염환자수궤분위연구조(n=108)여대조조(n=108)。대조조급여표준삼련요법(오미랍서20 mg，아막서림1 g，극랍매소0.5 g，구복，2차/d，료정14 d)；연구조재대조조기출상，가용려탄산미편1 g，작복，3차/d，료정14 d。비교량조HP근제솔。연구조HP근제솔(80.6%)고우대조조(71.3%)，단량조상비무현저차이(χ2=2.5328，>0.05)；연구조중위궤양급십이지장구부궤양환자HP근제솔균체100%，균분별현저고우대조조(70.6%，73.9%)(<0.05)。연합응용려탄산미능증강표준삼련요법대HP、우기시소화성궤양환자HP적근제솔。
of To explore whether hydrotalcite combined with standard triple therapy is able to raise the eradication rate (HP). Total 216 HP patients were selected and randomly divided into a research group and a control group (n = 108 per group). The control group was treated with standard triple therapy (20 mg omerprazole, 1 g amoxicillin, 0.5 g clarithromycin, taking orally, 2 times per day, course of treatment =14 d); on the basis of this, the research group was treated with additional medicine: 1 g hydrotalcite tablets, chewing, 3 times per day; the course of treatment was14 d. The eradication rates were compared between two groups. The eradication rate in the research group (80.6%) was higher than that in the control group (71.3%), but there is no obvious difference between the two groups (χ2=2.5328, >0.05). In the research group, the HP eradication rate of patients with gastrelcoma and duodenal ampulla reached 100%, which was evidently higher than that in the control group (70.6%, 73.9%) ( < 0.05). Hydrotalcite combined with standard triple therapy is able to raise the HP eradication rate, for patients with peptic ulcer in particular.