CAJ | 학술논문

探讨吉非替尼治疗老年非小细胞肺癌(NSCLC)合并脑转移的疗效及可行性。以吉非替尼治疗的老年NSCLC合并脑转移患者68例为观察组，给予吉非替尼250 mg/d口服；接受化疗的老年NSCLC合并脑转移患者36例为对照组，给予VIP化疗方案。对比两组治疗效果、生活质量及药物不良反应。观察组治疗有效率(47.1%)显著高于对照组(22.2%)，临床获益率(79.4%)亦显著高于对照组(44.4%)(均<0.05)。治疗后，观察组整体生活质量、躯体功能、社会功能得分较对照组显著升高(<0.05)；各项症状评分除恶心、呕吐外，观察组均显著低于对照组(<0.05)。吉非替尼对老年NSCLC合并脑转移有一定的疗效，可改善患者的生活质量，并且安全可行，适合临床应用。
탐토길비체니치료노년비소세포폐암(NSCLC)합병뇌전이적료효급가행성。이길비체니치료적노년NSCLC합병뇌전이환자68례위관찰조，급여길비체니250 mg/d구복；접수화료적노년NSCLC합병뇌전이환자36례위대조조，급여VIP화료방안。대비량조치료효과、생활질량급약물불량반응。관찰조치료유효솔(47.1%)현저고우대조조(22.2%)，림상획익솔(79.4%)역현저고우대조조(44.4%)(균<0.05)。치료후，관찰조정체생활질량、구체공능、사회공능득분교대조조현저승고(<0.05)；각항증상평분제악심、구토외，관찰조균현저저우대조조(<0.05)。길비체니대노년NSCLC합병뇌전이유일정적료효，가개선환자적생활질량，병차안전가행，괄합림상응용。
To explore the curative effect and feasibility of Gefitnib in treatment of the senile patients with non-small cell lung cancer (NSCLC) complicated with brain metastases. Total 68 senile patients with NSCLC complicated with brain metastases to receive treatment with Gefitnib were selected to constitute the observation group and were treated with Gefitnib (taken orally, 250 mg per day); another total 36 patients with NSCLC complicated with brain metastases to receive chemotherapy were selected to constitute the control group and were treated with VIP chemotherapy. And then, the curative effects, life qualities and drug adverse reactions were compared between two groups. The treatment efficiency in the observation group (47.1%) was significantly higher than that in the control group (22.2%), and the clinical benefit rate in the observation group (79.4%) was also significantly higher than that in the control group (44.4%) (all < 0.05). After the treatment, the scores of the overall life quality, somatic function and social function in the observation group were significantly higher than those in the control group ( < 0.05); all symptom scores (except nausea and vomiting) in the observation were significantly lower than those in the control group ( < 0.05). Gefitnib has a certain curative effect in treatment of the senile patients with NSCLC complicated with brain metastases and can improve the life quality of the patients, and also it is safe and feasible, so it is suitable for clinical application.