CAJ | 학술논문

目的：观察胸腔灌注奈达铂（ NDP）治疗非小细胞肺癌（ NSCLC）恶性胸腔积液的临床效、患者生活质量及不良反应。方法随机将30例确诊为NSCLC（Ⅲb期）恶性胸腔积液患者分为两组，每组15例。观察组采用NDP治疗。对照组采用顺铂（ DDP ）治疗。比较两组临床疗效、不良反应及患者生活质量。结果观察组有效率、消化道不良反应发生率、Karnofsky 评分以及生存期均显著优于对照组，差异具有统计学意义（ P＜0．05）。结论采用NDP 胸腔灌注治疗NSCLC 引起的恶性胸腔积液，临床效果显著，不良反应少，安全性高。
목적：관찰흉강관주내체박（ NDP）치료비소세포폐암（ NSCLC）악성흉강적액적림상효、환자생활질량급불량반응。방법수궤장30례학진위NSCLC（Ⅲb기）악성흉강적액환자분위량조，매조15례。관찰조채용NDP치료。대조조채용순박（ DDP ）치료。비교량조림상료효、불량반응급환자생활질량。결과관찰조유효솔、소화도불량반응발생솔、Karnofsky 평분이급생존기균현저우우대조조，차이구유통계학의의（ P＜0．05）。결론채용NDP 흉강관주치료NSCLC 인기적악성흉강적액，림상효과현저，불량반응소，안전성고。
Objective To observe the chest cavity perfusion of nida platinum (NDP) treatment of non-small cell lung cancer ( NSCLC) patients with the clinical effect of the treatment of malignant pleural effusion, life quality and ad-verse reactions.Methods Random 30 patients diagnosed with NSCLC (Ⅲb) malignant pleural effusion patients were divided into two groups, 15 cases in each group.The observation group was treated using NDP.The control group treated with cisplatin (DDP).Compare two groups of patients with clinical efficacy, adverse reactions and quality of life.Re-sults Observation group efficiently, the incidence of gastrointestinal adverse reactions, Karnofsky score and survival were significantly better than the control group, but it was not statisticated analysis because of less cases.the difference is statistically significant (P<0.05).Conclusions Using NDP pleural perfusion treatment of NSCLC malignant pleural effusion, clinical effect, less adverse reaction, high safety.