CAJ | 학술논문

对玉液颗粒制剂工艺参数进行了研究，选取了最优的制备工艺参数．利用正交设计，采用君药黄芪的主要成分黄芪甲苷以及提取物的干膏收率为指标，筛选了工艺参数．确定最佳提取工艺条件为加8倍量的水提取3次，每次1 h；最佳一步制粒工艺为泵药速度3000 mL／h，药液相对密度1．08～1.06 mg／mL和进风温度170℃；一步制粒的主要技术参数为泵进药液速度55～60 mL／min；喷雾过程压力0．3 MPa；蒸汽压力0．5 MPa；进料温度为55～50℃；进风口温度为76～86℃；出风口温度为50～45℃．本实验选取的工艺参数条件适用于玉液颗粒的工业生产．
대옥액과립제제공예삼수진행료연구，선취료최우적제비공예삼수．이용정교설계，채용군약황기적주요성분황기갑감이급제취물적간고수솔위지표，사선료공예삼수．학정최가제취공예조건위가8배량적수제취3차，매차1 h；최가일보제립공예위빙약속도3000 mL／h，약액상대밀도1．08～1.06 mg／mL화진풍온도170℃；일보제립적주요기술삼수위빙진약액속도55～60 mL／min；분무과정압력0．3 MPa；증기압력0．5 MPa；진료온도위55～50℃；진풍구온도위76～86℃；출풍구온도위50～45℃．본실험선취적공예삼수조건괄용우옥액과립적공업생산．
In this paper , formulation process parameters of Yuye granules were studied , and the optimal process parameters were selected .The process parameters were optimized using orthogonal design , the main component of the use of herbs and Astragaloside Astragalus ex-tract yield of dry extract indicators .The optimum extraction conditions were as follows: 8 times the amount of water for extracting three times , 1 h each time;the best one step granu-lation process for drug pump speed was 3 000 mL/h, the relative density of the liquid was 1.08~1.06 mg/mL and feed air temperature was 170℃.The main technical parameters of one step granulation were liquid speed of 55~60 mL/min, spray pressure of 0.3 MPa, va-por pressure of 0.5 MPa, the material temperature of 55~50 ℃, inlet air temperature of 76~86℃, the air temperature of 50~45℃.The selected process parameters are suitable for industrial mass production of Yuye particles .