CAJ | 학술논문

目前临床上使用的羟基喜树碱制剂存在水溶性差、半衰期短、稳定性差、不良反应大等问题，限制了其推广应用。近年来出现的纳米靶向给药系统在实现靶向性输送药物、缓释药物、提高难溶性药物的生物利用度、降低药物的不良反应等方面表现出良好的应用前景，成为国内外学者研究热点之一。作者对近年来出现的羟基喜树碱纳米靶向给药系统的种类进行综述，并阐述各类载药系统的特点及其进一步应用的理论依据。
목전림상상사용적간기희수감제제존재수용성차、반쇠기단、은정성차、불량반응대등문제，한제료기추엄응용。근년래출현적납미파향급약계통재실현파향성수송약물、완석약물、제고난용성약물적생물이용도、강저약물적불량반응등방면표현출량호적응용전경，성위국내외학자연구열점지일。작자대근년래출현적간기희수감납미파향급약계통적충류진행종술，병천술각류재약계통적특점급기진일보응용적이론의거。
The current formulations of the natural anti-cancer product hydroxycamptothecine display poor water solubility and stability , short half-life, adverse effects ( or toxicity ) , and many other issues to limit its clinical use .Nano targeted drug delivery systems have emerged in recent years and shown promising prospects in targeted drug delivery , controlling drug release , improving the bioavailability of poorly soluble drugs , and reducing side effects of toxic drugs .Thus, nano tar-geting drug delivery system has attracted considerable attention as a novel and potentially effective and safe approach to deliver a variety of drugs , particularly natural anti-cancer medicines including hydroxycamptothecin .This article reviews the recent status of various nano targeted and other drug delivery systems for hydroxycamptothecin , which are currently under investigation and development , and discusses their characteristics and theoretical benefits for future clinical applications .