CAJ | 학술논문

树突状细胞（dendritic cell，DC）是机体内强大的抗原提呈细胞，在机体特异性免疫应答过程中发挥着重要的作用。 DC在机体抗肿瘤中的作用，尤其是2010年第1个以DC为基础的DC疫苗产品（ Sipuleu-cel-T或Provenge）获得美国食品和药品管理局批准用于治疗前列腺癌以来，以DC为基础的肿瘤免疫治疗正成为国内外研究的热点之一。作者对DC疫苗在抗肿瘤免疫治疗中的应用进展作一综述。
수돌상세포（dendritic cell，DC）시궤체내강대적항원제정세포，재궤체특이성면역응답과정중발휘착중요적작용。 DC재궤체항종류중적작용，우기시2010년제1개이DC위기출적DC역묘산품（ Sipuleu-cel-T혹Provenge）획득미국식품화약품관리국비준용우치료전렬선암이래，이DC위기출적종류면역치료정성위국내외연구적열점지일。작자대DC역묘재항종류면역치료중적응용진전작일종술。
Dendritic cell(DC) is a kind of powerful professional antigen presenting cells in human, which plays a key role in the antigen specific immune response .Plenty of researches have proved the important role of DC in anti-cancer activity .Since the first DC-based product named Sipu-teucel-T or Provenge was licensed for treating the prostate cancer in 2010, especially the DC-based immunotherapy has been the one of the "hotspots"of anticancer research .We here summarize recent advances in the clinical research of DC-based anticancer immunotherapy .