中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
11期
909-911,915
,共4页
徐松明%许晓华%孙云鹰%金雯佳
徐鬆明%許曉華%孫雲鷹%金雯佳
서송명%허효화%손운응%금문가
硫辛酸%糖尿病足%氧化应激%炎症
硫辛痠%糖尿病足%氧化應激%炎癥
류신산%당뇨병족%양화응격%염증
alprostadil%diabetic foot%oxidative stress%inflammation
目的：探讨硫辛酸对早期糖尿病足患者氧化应激、炎症反应的影响。方法90例糖尿病足患者随机分成观察组和对照组（均45例），2组常规治疗相同，在此基础上，观察组给予硫辛酸胶囊，1次0.2 g，1日3次，疗程为4周。用硫代巴比妥酸反应法检测超氧化物歧化酶（SOD）和丙二醛（MDA），用酶联免疫吸附法检测血清晚期蛋白氧化产物（ AOPPs ）、血管细胞黏附分子－1（VCAM－1）、成纤维细胞生长因子2（FGF－2）和肿瘤坏死因子－α（TNF－α），用电化学发光法检测白介素－6（IL－6），并比较2组治疗前和治疗后上述指标的差异。结果观察组有效率（84.44％）显著高于对照组（64.44％）（ P ＜0.05）；治疗后，观察组AOPPs、MDA、VCAM－1、FGF2、TNF－α和IL－6均显著低于对照组，而SOD显著高于对照组（均P＜0.05）。结论硫辛酸可提高糖尿病足治疗的有效率，改善氧化应激反应和炎症状态。
目的：探討硫辛痠對早期糖尿病足患者氧化應激、炎癥反應的影響。方法90例糖尿病足患者隨機分成觀察組和對照組（均45例），2組常規治療相同，在此基礎上，觀察組給予硫辛痠膠囊，1次0.2 g，1日3次，療程為4週。用硫代巴比妥痠反應法檢測超氧化物歧化酶（SOD）和丙二醛（MDA），用酶聯免疫吸附法檢測血清晚期蛋白氧化產物（ AOPPs ）、血管細胞黏附分子－1（VCAM－1）、成纖維細胞生長因子2（FGF－2）和腫瘤壞死因子－α（TNF－α），用電化學髮光法檢測白介素－6（IL－6），併比較2組治療前和治療後上述指標的差異。結果觀察組有效率（84.44％）顯著高于對照組（64.44％）（ P ＜0.05）；治療後，觀察組AOPPs、MDA、VCAM－1、FGF2、TNF－α和IL－6均顯著低于對照組，而SOD顯著高于對照組（均P＜0.05）。結論硫辛痠可提高糖尿病足治療的有效率，改善氧化應激反應和炎癥狀態。
목적：탐토류신산대조기당뇨병족환자양화응격、염증반응적영향。방법90례당뇨병족환자수궤분성관찰조화대조조（균45례），2조상규치료상동，재차기출상，관찰조급여류신산효낭，1차0.2 g，1일3차，료정위4주。용류대파비타산반응법검측초양화물기화매（SOD）화병이철（MDA），용매련면역흡부법검측혈청만기단백양화산물（ AOPPs ）、혈관세포점부분자－1（VCAM－1）、성섬유세포생장인자2（FGF－2）화종류배사인자－α（TNF－α），용전화학발광법검측백개소－6（IL－6），병비교2조치료전화치료후상술지표적차이。결과관찰조유효솔（84.44％）현저고우대조조（64.44％）（ P ＜0.05）；치료후，관찰조AOPPs、MDA、VCAM－1、FGF2、TNF－α화IL－6균현저저우대조조，이SOD현저고우대조조（균P＜0.05）。결론류신산가제고당뇨병족치료적유효솔，개선양화응격반응화염증상태。
Objective To explore the effect of alprostadil on oxidative stress and inflammation in patients with diabetic foot.Methods Ninety diabetic foot patients were randomly divided into the observe group ( n=45)and the control group(n =45).They all accepted the conventional treatment, but the patients in the observed group were given the treatment of alprostadil capsules, 1 time 0.2 g, 3 times a day, for 4 weeks.The concentrations of superoxide dismutase ( SOD ) and malondialdehyde ( MDA) were detected by thiobarbituric acid reaction.The concentrations of advanced oxidation protein products ( AOPPs ) , vascular cell adhesion molecule-1 ( VCAM -1 ) , fibroblast growth factor 2 ( FGF -2 ) and tumor necrosis factor alpha ( TNF -alpha ) were detected by enzyme linked immunosorbent assay.And the concentration of interleukin -6 ( IL-6) was detected by the electrochemical luminescence method.The concentrations of SOD, MDA, AOPPs, VCAM-1, FGF-2, IL-6 and TNF-alpha were compared between the two groups before and after treat-ment.Results The efficiency in the observation group (84.44%) was significantly higher than that in control group (64.44%).After treatment, the AOPPs, MDA, VCAM -1, FGF2, TNF -alpha and IL-6 in the observation group were significantly lower than that in the control group ( P<0.05) , and the SOD in the observed group was significantly higher than that in the control group ( P <0.05 ).Conclusion Alprostadil couldimprove the clinical efficacy by improving oxidative stress and inflammation in diabetic foot patients.
